YME1L1 blocking peptide

YME1L1 Blocking Peptide

Cat. Num. AAA9620729

• Gene Names: YME1L1; FTSH; MEG4; PAMP; YME1L
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: YME1L1; YME1L1 Blocking Peptide; ATP dependent metalloprotease FtsH1 homolog; ATP-dependent metalloprotease FtsH1; ATP-dependent zinc metalloprotease YME1L1; FTSH1; Meg-4; MEG4; PAMP; Presenilin-associated metalloprotease; UNQ1868/PRO4304; YME1 like 1; YME1-like protein 1; YME1L; Yme1l1; YMEL1_HUMAN; YME1L1 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for YME1L1 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for YME1L1 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 359718987
• NCBI GeneID: 10730
• NCBI Accession #: NP_001240795.1
• NCBI GenBank Nucleotide #: NM_001253866.1
• UniProt Accession #: Q96TA2; Q5T8D9; Q9H1Q0; Q9UMR9; B4DNM1; D3DRV8; D3DRV9
• Molecular Weight: 86,455 Da
• NCBI Official Full Name: ATP-dependent zinc metalloprotease YME1L1 isoform 4
• NCBI Official Synonym Full Names: YME1-like 1 ATPase
• NCBI Official Symbol: YME1L1
• NCBI Official Synonym Symbols: FTSH; MEG4; PAMP; YME1L
• NCBI Protein Information: ATP-dependent zinc metalloprotease YME1L1; meg-4; YME1-like protein 1; ATP-dependent metalloprotease YME1L1; presenilin-associated metalloprotease; ATP-dependent metalloprotease FtsH1 homolog
• UniProt Protein Name: ATP-dependent zinc metalloprotease YME1L1
• Protein Family: ATP-dependent zinc metalloprotease
• UniProt Gene Name: YME1L1
• UniProt Synonym Gene Names: FTSH1; YME1L; PAMP
• UniProt Entry Name: YMEL1_HUMAN

Uniprot Description

YME1L1: Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Protease; EC 3.4.24.-

Chromosomal Location of Human Ortholog: 10p14

Cellular Component: integral to membrane; membrane; mitochondrial inner membrane; mitochondrion; nucleoplasm

Molecular Function: ATP binding; ATP-dependent peptidase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity

Biological Process: cell proliferation; misfolded or incompletely synthesized protein catabolic process; mitochondrion organization and biogenesis