Plasma protease C1 inhibitor Recombinant Protein | IC1 recombinant protein

Recombinant mouse Plasma protease C1 inhibitor

Cat. Num. AAA9420665

• Gene Names: Serping1; C1nh; C1INH
• Reactivity: Mouse
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Plasma protease C1 inhibitor; Recombinant mouse Plasma protease C1 inhibitor; C1 esterase inhibitorC1-inhibiting factorSerpin G1; IC1 recombinant protein

• Host: E Coli
• Reactivity: Mouse
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Partial of the Full Length of 23-504aa, 31-503aa

• Tag Info: His-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for IC1 recombinant protein

Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complent activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. May inhibit chymotrypsin and kallikrein.

NCBI and Uniprot Product Information

• NCBI GI #: 163914390
• NCBI GeneID: 12258
• NCBI Accession #: NP_033906.2
• NCBI GenBank Nucleotide #: NM_009776.3
• UniProt Accession #: P97290; O88330; Q99M43; Q9QX09; A2ATR7
• Molecular Weight: 56.4kD
• NCBI Official Full Name: plasma protease C1 inhibitor
• NCBI Official Synonym Full Names: serine (or cysteine) peptidase inhibitor, clade G, member 1
• NCBI Official Symbol: Serping1
• NCBI Official Synonym Symbols: C1nh; C1INH
• NCBI Protein Information: plasma protease C1 inhibitor
• UniProt Protein Name: Plasma protease C1 inhibitor
• Protein Family: Plasma protease C1 inhibitor
• UniProt Gene Name: Serping1
• UniProt Synonym Gene Names: C1nh; C1 Inh; C1Inh

Uniprot Description

SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2|2 D

Cellular Component: extracellular space

Molecular Function: complement binding; serine-type endopeptidase inhibitor activity

Biological Process: negative regulation of complement activation, lectin pathway