Plasma protease C1 inhibitor (Serping1) Recombinant Protein | SERPING1 recombinant protein

Recombinant Mouse Plasma protease C1 inhibitor (Serping1), partial

Cat. Num. AAA964902

• Gene Names: Serping1; C1nh; C1INH
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Plasma protease C1 inhibitor (Serping1); Recombinant Mouse Plasma protease C1 inhibitor (Serping1); partial; C1 esterase inhibitor; C1-inhibiting factor; Serpin G1; SERPING1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 31-503aa; Partial
• Sequence: TQDPLEAQAKSRESFPERDDSWSPPEPTVLPSTWPTTSVAITITNDTMGKVANESFSQHSQPAAQLPTDSPGQPPLNSSSQPSTASDLPTQATTEPFCPEPLAQCSDSDRDSSEAKLSEALTDFSVKLYHAFSATKMAKTNMAFSPFSIASLLTQVLLGAGDSTKSNLESILSYPKDFACVHQALKGFSSKGVTSVSQIFHSPDLAIRDTYVNASQSLYGSSPRVLGPDSAANLELINTWVAENTNHKIRKLLDSLPSDTCLVLLNAVYLSAKWKITFEPKKMMAPFFYKNSMIKVPMMSSVKYPVAQFDDHTLKAKVGQLQLSHNLSFVIVVPVFPKHQLKDVEKALNPTVFKAIMKKLELSKFLPTYLTMPHIKVKSSQDMLSVMEKLEFFDFTYDLNLCGLTEDPDLQVSAMKHETVLELTESGVEAAAASAISFGRSLPIFEVQRPFLFLLWDQQHRFPVFMGRVYDPR

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for SERPING1 recombinant protein

Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complent activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. May inhibit chymotrypsin and kallikrein.

References

The sequence of a cDNA encoding functional murine C1-inhibitor protein.Russell J.A., Whaley K., Heaphy S.Biochim. Biophys. Acta 1352:156-160(1997) Molecular cloning, gene structure and expression profile of mouse C1 inhibitor.Lener M., Vinci G., Duponchel C., Meo T., Tosi M.Eur. J. Biochem. 254:117-122(1998) Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) Proteome-wide characterization of N-glycosylation events by diagonal chromatography.Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.J. Proteome Res. 5:2438-2447(2006) Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.Bernhard O.K., Kapp E.A., Simpson R.J.J. Proteome Res. 6:987-995(2007)

NCBI and Uniprot Product Information

• NCBI GI #: 163914390
• NCBI GeneID: 12258
• NCBI Accession #: NP_033906.2
• NCBI GenBank Nucleotide #: NM_009776.3
• UniProt Accession #: P97290; O88330; Q99M43; Q9QX09; A2ATR7
• Molecular Weight: 56.3 kDa
• NCBI Official Full Name: plasma protease C1 inhibitor
• NCBI Official Synonym Full Names: serine (or cysteine) peptidase inhibitor, clade G, member 1
• NCBI Official Symbol: Serping1
• NCBI Official Synonym Symbols: C1nh; C1INH
• NCBI Protein Information: plasma protease C1 inhibitor
• UniProt Protein Name: Plasma protease C1 inhibitor
• Protein Family: Plasma protease C1 inhibitor
• UniProt Gene Name: Serping1
• UniProt Synonym Gene Names: C1nh; C1 Inh; C1Inh
• UniProt Entry Name: IC1_MOUSE

Uniprot Description

SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family.

Protein type: Secreted, signal peptide; Secreted

Cellular Component: extracellular region; extracellular space

Molecular Function: complement binding; protease inhibitor activity; serine-type endopeptidase inhibitor activity

Biological Process: blood coagulation; complement activation, classical pathway; fibrinolysis; hemostasis; immune system process; innate immune response; negative regulation of complement activation, lectin pathway; negative regulation of peptidase activity