Western Blot (WB)
(Western blot analysis of IL-31 in RAW264.7 cell lysate with IL-31 antibody at (A) 2.5, (B) 5 and (C) 10 ug/mL.)
Rabbit anti-Mouse IL-31 Polyclonal Antibody | anti-IL-31 antibody
IL-31 Antibody
Reactivity
Mouse
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Affinity chromatography purified via peptide column
Synonyms
IL-31; Polyclonal Antibody; IL-31 Antibody; Interleukin 31; IL31; anti-IL-31 antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
163
Applicable Applications for anti-IL-31 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Immunogen Type
Peptide
Immunogen Description
Raised against a 16 amino acid peptide from near the amino terminus of mouse IL-31.
Target Name
IL-31
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Western Blot (WB)
(Western blot analysis of IL-31 in RAW264.7 cell lysate with IL-31 antibody at (A) 2.5, (B) 5 and (C) 10 ug/mL.)
Western Blot (WB)
(Western blot analysis of IL-31 in RAW264.7 cell lysate with IL-31 antibody at (A) 2.5, (B) 5 and (C) 10 ug/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of IL-31 in rat skeletal muscle tissue with IL-31 antibody at 10 ug/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of IL-31 in rat skeletal muscle tissue with IL-31 antibody at 10 ug/mL.)
Related Product Information for anti-IL-31 antibody
Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
Product Categories/Family for anti-IL-31 antibody
NCBI and Uniprot Product Information
NCBI GI #
Molecular Weight
18,120 Da
NCBI Official Full Name
interleukin 31
UniProt Protein Name
Interleukin-31
UniProt Gene Name
Il31
UniProt Synonym Gene Names
IL-31
UniProt Entry Name
IL31_MOUSE
Uniprot Description
IL31: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity
Protein type: Cytokine; Secreted, signal peptide; Secreted
Cellular Component: extracellular space; extracellular region
Molecular Function: cytokine activity
Biological Process: immune system process
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Product Notes
The IL-31 il31 (Catalog #AAA9411353) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IL-31 Antibody reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's IL-31 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the IL-31 il31 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-31, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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