Rabbit anti-Mouse TRIM30 Polyclonal Antibody | anti-TRIM30 antibody

TRIM30 Antibody

Cat. Num. AAA9408944

• Gene Names: Trim30a; Rpt1; Rpt-1; Trim30
• Reactivity: Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: TRIM30; Polyclonal Antibody; TRIM30 Antibody; Tripartite motif-containing 30; Rpt-1; Rpt1; down regulatory protein of interleukin 2 receptor; anti-TRIM30 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 496

• Applicable Applications for anti-TRIM30 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 16 amino acid peptide near the carboxy terminus of the mouse TRIM30.
• Target Name: TRIM30
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of TRIM30 in mouse spleen tissue lysate with TRIM30 antibody at 1 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of TRIM30 in mouse ovary tissue with TRIM30 antibody at 10 ug/mL.)

Related Product Information for anti-TRIM30 antibody

TRIM30 belongs to a family of the tripartite motif (TRIM) proteins involved in the regulation of cell proliferation, differentiation, development, oncogenesis, apoptosis and antiviral responses. The TRIM protein family is an expanding family of RING ('really interesting new gene') proteins, also known as RBCC proteins as they contain an RBCC motif, which comprises a RING domain, one or two B-boxes and a predicted coiled-coil region. Studies have shown that some TRIM family members are critical to innate immunity; TRIM5, TRIM19 and TRIM25, for example, have been shown to restrict viral infection. A recent study shows that TRIM30 functions as a negative modulator of the TLR signaling pathway, by targeting TAB2 and TAB3, and contributes to the inhibition of TLR-mediated NF-kB activation. The importance of TRIM30 in the attenuation or termination of NF-kB activation suggests that targeting of TAB2 and TAB3 by TRIM30a may be a mechanism for modulating many types of immune responses.

Product Categories/Family for anti-TRIM30 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 125347379
• NCBI GeneID: 20128
• NCBI Accession #: NP_033125
• NCBI GenBank Nucleotide #: NM_009099.2
• Molecular Weight: 17,414 Da
• NCBI Official Full Name: tripartite motif-containing protein 30A
• NCBI Official Synonym Full Names: tripartite motif-containing 30A
• NCBI Official Symbol: Trim30a
• NCBI Official Synonym Symbols: Rpt1; Rpt-1; Trim30
• NCBI Protein Information: tripartite motif-containing protein 30A
• UniProt Protein Name: Tripartite motif-containing protein 30A
• UniProt Gene Name: Trim30a
• UniProt Synonym Gene Names: Rpt-1; Rpt1; Trim30
• UniProt Entry Name: TR30A_MOUSE

Uniprot Description

TRIM30A: Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, regulates activation of CASP1 and subsequent cleavage of IL1B and IL18. No activity detected against a range of retroviruses including a number of lentiviruses, gammaretroviruses and betaretroviruses

Cellular Component: cytoplasm; intracellular; nucleus

Molecular Function: DNA binding; zinc ion binding; metal ion binding

Biological Process: protein autoubiquitination; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of virion penetration into host cell; negative regulation of toll-like receptor signaling pathway; positive regulation of protein catabolic process; negative regulation of interleukin-6 production; negative regulation of tumor necrosis factor production