Rabbit anti-Human, Mouse MAP1 Polyclonal Antibody | anti-MAP1 antibody

MAP1 Antibody

Cat. Num. AAA9403513

• Gene Names: MOAP1; MAP-1; PNMA4
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: Affinity chromatography purified via peptide column
• Synonyms: MAP1; Polyclonal Antibody; MAP1 Antibody; anti-MAP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 351

• Applicable Applications for anti-MAP1 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 15 amino acid peptide from near the center of human MAP-1.
• Target Name: MAP1
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of MAP-1 in EL4 cell lysate with MAP-1 antibody (IN) at (A) 1, (B) 2, and (C) 4 ug/mL.)

Related Product Information for anti-MAP1 antibody

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo. It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.

Product Categories/Family for anti-MAP1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 19923584
• NCBI GeneID: 64112
• NCBI Accession #: NP_071434
• NCBI GenBank Nucleotide #: NM_022151.4
• Molecular Weight: 39,513 Da
• NCBI Official Full Name: modulator of apoptosis 1
• NCBI Official Synonym Full Names: modulator of apoptosis 1
• NCBI Official Symbol: MOAP1
• NCBI Official Synonym Symbols: MAP-1; PNMA4
• NCBI Protein Information: modulator of apoptosis 1
• UniProt Protein Name: Modulator of apoptosis 1
• Protein Family: T-kininogen
• UniProt Gene Name: MOAP1
• UniProt Synonym Gene Names: PNMA4; MAP-1; MAP1
• UniProt Entry Name: MOAP1_HUMAN

NCBI Description

The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008]

Uniprot Description

MOAP1: Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Belongs to the PNMA family.

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: mitochondrial outer membrane; mitochondrion; cytoplasm; cytosol

Molecular Function: protein binding; ubiquitin protein ligase binding

Biological Process: induction of apoptosis via death domain receptors; DNA damage response, signal transduction resulting in induction of apoptosis; positive regulation of apoptosis; protein insertion into mitochondrial membrane during induction of apoptosis