Rabbit anti-Human MAP1/MOAP1 Polyclonal Antibody | anti-MOAP1 antibody

Anti-MAP1/MOAP1 Antibody, Rabbit Polyclonal

Cat. Num. AAA8100838

• Gene Names: MOAP1; MAP-1; PNMA4
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: MAP1/MOAP1; Polyclonal Antibody; Anti-MAP1/MOAP1 Antibody; Rabbit Polyclonal; MAP1 Antibody; Rabbit PAb; Antigen Affinity Purified; modulator of apoptosis 1; Anti-MAP-1 Antibody; Anti-PNMA4 Antibody; anti-MOAP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human MAP1
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; PBS, pH7.0 with 0.03% Proclin300

• Applicable Applications for anti-MOAP1 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:200-1:1000
• Immunogen: A synthetic peptide corresponding to the C-terminus of the Human MAP1
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human MAP1, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human MOAP1 in human brain with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-MOAP1 antibody

MOAP1 (Modulator Of Apoptosis 1) is a Protein Coding gene. The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. The encoded protein belongs to the PNMA family. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. MOAP1 is widely expressed in the brain, heart, and other tissues. Enforced miR-1228 expression can reduce MOAP1 expression and delay the progression of stress-induced cell apoptosis. The miR-1228 inhibition of cellular apoptosis is significantly attenuated by repressing MOAP1 expression, suggesting the direct interaction between miR-1228 and MOAP1 protein. Among its related pathways are Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins.

NCBI and Uniprot Product Information

• NCBI GI #: 19923584
• NCBI GeneID: 64112
• NCBI Accession #: NP_071434.2
• NCBI GenBank Nucleotide #: NM_022151.4
• UniProt Accession #: Q96BY2; Q9H833; Q9HAS1; B2RDF6
• Molecular Weight: 39,513 Da
• NCBI Official Full Name: modulator of apoptosis 1
• NCBI Official Synonym Full Names: modulator of apoptosis 1
• NCBI Official Symbol: MOAP1
• NCBI Official Synonym Symbols: MAP-1; PNMA4
• NCBI Protein Information: modulator of apoptosis 1; MAP1; paraneoplastic Ma antigen family member 4; paraneoplastic antigen Ma4; paraneoplastic antigen like 4
• UniProt Protein Name: Modulator of apoptosis 1
• Protein Family: Modulator of apoptosis
• UniProt Gene Name: MOAP1
• UniProt Synonym Gene Names: PNMA4; MAP-1; MAP1
• UniProt Entry Name: MOAP1_HUMAN

NCBI Description

The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008]

Uniprot Description

MOAP1: Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Belongs to the PNMA family.

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: mitochondrial outer membrane; mitochondrion; cytoplasm; cytosol

Molecular Function: protein binding; ubiquitin protein ligase binding

Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; induction of apoptosis via death domain receptors; protein insertion into mitochondrial membrane during induction of apoptosis; positive regulation of apoptosis