Rabbit anti-Human, Mouse MOAP1 / MAP1 Polyclonal Antibody | anti-MOAP1 antibody

Rabbit Polyclonal to Human MOAP1 / MAP1

Cat. Num. AAA240332

• Gene Names: MOAP1; MAP-1; PNMA4
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: MOAP1 / MAP1; Polyclonal Antibody; Rabbit Polyclonal to Human MOAP1 / MAP1; Anti-MOAP1 / MAP1 Antibody (Internal) IHC-plus; MOAP1; MAP-1; MAP1; Modulator of apoptosis 1; Paraneoplastic antigen like 4; Paraneoplastic antigen Ma4; PNMA4; Human MOAP1; anti-MOAP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: 15 amino acid peptide from near the center of human MAP-1
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 351

• Applicable Applications for anti-MOAP1 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (2.5 ug/ml), WB (1 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
• Target Species: Human
• Immunogen Description: Synthetic peptide from human MOAP1 / MAP1.
• Immunogen Type: Synthetic peptide
• Immunogen: MOAP1 / MAP1 antibody was raised against synthetic peptide from human MOAP1 / MAP1.
• Antigen Modification: Internal
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-MOAP1 / MAP1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(Western blot of MAP-1 in EL4 cell lysate with MAP-1 antibody (IN) at (A) 1, (B) 2, and (C) 4 ug/ml.)

Related Product Information for anti-MOAP1 antibody

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A related protein termed MAP-1 has recently been identified.

Product Categories/Family for anti-MOAP1 antibody

Family: Apoptosis

NCBI and Uniprot Product Information

• NCBI GI #: 19923584
• NCBI GeneID: 64112
• NCBI Accession #: NP_071434.2
• NCBI GenBank Nucleotide #: NM_022151.4
• UniProt Accession #: Q96BY2; Q9H833; Q9HAS1; B2RDF6
• Molecular Weight: 39,513 Da
• NCBI Official Full Name: modulator of apoptosis 1
• NCBI Official Synonym Full Names: modulator of apoptosis 1
• NCBI Official Symbol: MOAP1
• NCBI Official Synonym Symbols: MAP-1; PNMA4
• NCBI Protein Information: modulator of apoptosis 1; MAP1; paraneoplastic antigen Ma4; paraneoplastic antigen like 4; paraneoplastic Ma antigen family member 4
• UniProt Protein Name: Modulator of apoptosis 1
• Protein Family: Modulator of apoptosis
• UniProt Gene Name: MOAP1
• UniProt Synonym Gene Names: PNMA4; MAP-1; MAP1
• UniProt Entry Name: MOAP1_HUMAN

NCBI Description

The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008]

Uniprot Description

MOAP1: Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Belongs to the PNMA family.

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: mitochondrial outer membrane; mitochondrion; cytoplasm; cytosol

Molecular Function: protein binding; ubiquitin protein ligase binding

Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; induction of apoptosis via death domain receptors; positive regulation of apoptosis; protein insertion into mitochondrial membrane during induction of apoptosis