Human nuclear receptor subfamily 2, group C, member 1 ELISA Kit | NR2C1 elisa kit
Human Nuclear receptor subfamily 2 group C member 1, NR2C1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
NR2C1: Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid- regulated preadipocyte proliferation. Belongs to the nuclear hormone receptor family. NR2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor; DNA-binding
Chromosomal Location of Human Ortholog: 12q22
Cellular Component: nucleoplasm; PML body
Molecular Function: protein binding; protein homodimerization activity; DNA binding; zinc ion binding; sequence-specific DNA binding; histone deacetylase binding; steroid hormone receptor activity; receptor activity; transcription factor activity
Biological Process: transcription initiation from RNA polymerase II promoter; steroid hormone mediated signaling; gene expression; positive regulation of retinoic acid receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter
Research Articles on NR2C1
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Product Notes
The Human NR2C1 nr2c1 (Catalog #AAA9336841) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9336841 ELISA Kit recognizes Human NR2C1. It is sometimes possible for the material contained within the vial of "nuclear receptor subfamily 2, group C, member 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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