Mouse eukaryotic translation initiation factor 2-alpha kinase 2 ELISA Kit | EIF2AK2 elisa kit
Mouse Interferon-induced, double-stranded RNA-activated protein kinase, EIF2AK2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
PKR: a protein kinase of the PEK family. Upon binding double-stranded RNA, it becomes autophosphorylated and activated. Phosphorylates and inhibits the alpha subunit of eIF2 alpha, which leads to an inhibition of the initiation of protein synthesis. Controls the activation of several transcription factors such as NF-kappaB, p53 and Stats. Mediates apoptosis induced by many different stimuli, such as LPS, TNF-alpha, viral infection and serum starvation.
Protein type: Kinase, protein; Protein kinase, Other; Translation; EC 2.7.10.2; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; PEK family
Cellular Component: membrane; perinuclear region of cytoplasm; cytoplasm; nucleus
Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; RNA binding; protein-tyrosine kinase activity; double-stranded RNA binding; transferase activity, transferring phosphorus-containing groups; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; kinase activity; ATP binding; protein kinase activity
Biological Process: positive regulation of cytokine production; translation; transcription, DNA-dependent; activation of MAPKK activity; unfolded protein response; immune system process; positive regulation of apoptosis; response to virus; response to toxin; protein amino acid autophosphorylation; response to lipopolysaccharide; protein amino acid phosphorylation; positive regulation of stress-activated MAPK cascade; positive regulation of chemokine production; activation of NF-kappaB transcription factor; response to vitamin E; negative regulation of viral genome replication; regulation of transcription, DNA-dependent; negative regulation of translation; innate immune response; negative regulation of osteoblast proliferation; phosphorylation; defense response to virus; negative regulation of apoptosis
Research Articles on EIF2AK2
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Product Notes
The Mouse EIF2AK2 eif2ak2 (Catalog #AAA9328176) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9328176 ELISA Kit recognizes Mouse EIF2AK2. It is sometimes possible for the material contained within the vial of "eukaryotic translation initiation factor 2-alpha kinase 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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