Rat ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) ELISA Kit | UCHL3 elisa kit
Rat Ubiquitin carboxyl-terminal hydrolase isozyme L3, UCHL3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
mouse homolog is an enzyme involved in proteolytic processing of polymeric ubiquitin [RGD, Feb 2006]
Uniprot Description
UCHL3: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin- signaling and insulin-induced adipogenesis. Required for stress- response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders. Preferentially binds diubiquitin; the interaction does not hydrolyze diubiquitin but, in vitro, inhibits the hydrolyzing activity on other substrates. Highly expressed in heart, skeletal muscle, and testis. Inhibited by monoubiquitin and diubiquitin. Belongs to the peptidase C12 family.
Protein type: Ubiquitin conjugating system; EC 3.4.19.12; Protease
Cellular Component: nucleoplasm; cytoplasm; intracellular; nucleus
Molecular Function: peptidase activity; ubiquitin binding; ubiquitin-specific protease activity
Biological Process: ubiquitin-dependent protein catabolic process; cellular response to insulin stimulus; retina development in camera-type eye; eating behavior; positive regulation of fat cell differentiation; protein catabolic process; proteolysis; adult walking behavior
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Product Notes
The Rat UCHL3 uchl3 (Catalog #AAA9326028) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9326028 ELISA Kit recognizes Rat UCHL3. It is sometimes possible for the material contained within the vial of "ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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