Western Blot (WB)
(SCRIB Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the SCRIB antibody detected the SCRIB protein (arrow).)
Rabbit anti-Human SCRIB Polyclonal Antibody | anti-SCRIB antibody
SCRIB Antibody (N-term)
Western Blot (WB)
(SCRIB Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the SCRIB antibody detected the SCRIB protein (arrow).)
Western Blot (WB)
(SCRIB Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the SCRIB antibody detected the SCRIB protein (arrow).)
targeted to epithelial adherens junctions and neuronal presynaptic
compartments. SCRIB and its orthologs in vertebrates and
invertebrates participate in cell polarization (summary by Nola et
al., 2008 [PubMed 18716323]).
Nagasaka, K., et al. Oncogene 29(38):5311-5321(2010)
Ivanov, A.I., et al. Am. J. Pathol. 176(1):134-145(2010)
Ouyang, Z., et al. Oncol. Res. 18 (11-12), 593-599 (2010) :
Arnaud, C., et al. FEBS Lett. 583(14):2326-2332(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Description
Scribble: may be involved in regulating neuroblast cortical polarity, cell size asymmetry and mitotic spindle asymmetry. A neoplastic tumor suppressor genes in Drosophila melanogaster. May play a role in the suppression of mammalian tumorigenesis. Gene ablation in the mouse causes severe neural tube defects. May be implicated in the etiology of human NTDs. Involved in the regulation of synaptic plasticity and synaptic vesicle dynamics. May be required to sustain synaptic vesicle concentrations at their sites of release. Targeted for ubiquitin-mediated degradation by the HPV E6 oncoprotein.
Protein type: Cell adhesion; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: nucleoplasm; presynaptic membrane; postsynaptic membrane; cell-cell adherens junction; basolateral plasma membrane; lamellipodium; leading edge; plasma membrane; intercellular junction
Molecular Function: protein binding
Biological Process: cell migration; wound healing; viral reproduction; positive regulation of apoptosis; establishment of apical/basal cell polarity; cochlear nucleus development; asymmetric protein localization; cell proliferation; cell-cell adhesion; positive chemotaxis; neural tube closure; synaptic vesicle endocytosis; negative regulation of mitotic cell cycle; auditory receptor cell stereocilium organization and biogenesis; synaptic vesicle targeting; positive regulation of receptor recycling; astrocyte cell migration
Research Articles on SCRIB
Similar Products
Product Notes
The SCRIB scrib (Catalog #AAA9210021) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 382-410. The SCRIB Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SCRIB can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the SCRIB scrib for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SCRIB, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
