Rabbit anti-Human NES Polyclonal Antibody | anti-NES antibody

NES Antibody

Cat. Num. AAA9410054

• Gene Names: NES; Nbla00170
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: NES; Polyclonal Antibody; NES Antibody; Nbla00170; anti-NES antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total NES protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 1.2 mg/ml (varies by lot)
• Sequence Length: 1621

• Applicable Applications for anti-NES antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:25-1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to residues near the C terminal of human nestin
• Target Name: NES
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/30.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human lymphoma cancer tissue using at dilution 1/30.)

Related Product Information for anti-NES antibody

Nestin is a type IV intermediate filament protein expressed by neuroepithelial stem cells and which has been proposed to represent a marker for putative islet stem cells. It is a high molecular weight protein with a terminus greater than 500 residues. Nestins are expressed by several types of cells during development, mostly in dividing cells of the Central Nervous System, Peripheral Nervous System and myogenic tissues. It also represents the progenitor population of neural stem cell origin. The role of nestin in dynamic cells, particularly structural organization of the cell, appears strictly regulated by phosphorylation, especially its integration into heterogeneous intermediate filaments together with vimentin or internexin. Nestin has recently received attention as a marker for detecting newly formed endothelial cells.

Product Categories/Family for anti-NES antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 38176300
• NCBI GeneID: 10763
• NCBI Accession #: NP_006608.1
• NCBI GenBank Nucleotide #: NM_006617.1
• UniProt Accession #: P48681; O00552; Q3LIF5; Q5SYZ6
• Molecular Weight: 177,439 Da
• NCBI Official Full Name: nestin
• NCBI Official Synonym Full Names: nestin
• NCBI Official Symbol: NES
• NCBI Official Synonym Symbols: Nbla00170
• NCBI Protein Information: nestin
• UniProt Protein Name: Nestin
• Protein Family: Nestin
• UniProt Gene Name: NES
• UniProt Entry Name: NEST_HUMAN

NCBI Description

This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]

Uniprot Description

nestin: an intermediate filament protein. It is expressed predominantly in stem cells of the central nervous system in the neural tube. Upon terminal neural differentiation, nestin is downregulated and replaced by neurofilaments.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 1q23.1

Cellular Component: intermediate filament cytoskeleton; cytoplasm; intermediate filament

Molecular Function: intermediate filament binding; structural molecule activity

Biological Process: positive regulation of intermediate filament depolymerization; central nervous system development; negative regulation of catalytic activity; cell projection morphogenesis; negative regulation of neuron apoptosis; brain development; negative regulation of protein binding; G2/M transition of mitotic cell cycle; embryonic camera-type eye development