Rat heat shock 70kDa protein 8 ELISA Kit | HSPA8 elisa kit

Rat Heat shock cognate 71 kDa protein, HSPA8 ELISA Kit

Cat. Num. AAA9322794

• Gene Names: Hspa8; Hsc70
• Reactivity: Rat
• Synonyms: heat shock 70kDa protein 8; Rat Heat shock cognate 71 kDa protein; HSPA8 ELISA Kit; Rat Heat shock cognate 71 kDa protein (HSPA8) ELISA kit; HSC54; HSC70; HSC71; HSP71; HSP73; HSPA10; LAP1; MGC131511; MGC29929; NIP71; LPS-associated protein 1; N-myristoyltransferase inhibitor protein 71; constitutive heat shock protein 70; heat shock 70kD p; HSPA8 elisa kit

• Reactivity: Rat

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 13242237
• NCBI GeneID: 24468
• NCBI Accession #: NP_077327.1
• NCBI GenBank Nucleotide #: NM_024351.2
• UniProt Accession #: P63018; P08109; P12225; Q4FZY7; Q62373; Q62374; Q62375
• Molecular Weight: 70,871 Da
• NCBI Official Full Name: heat shock cognate 71 kDa protein
• NCBI Official Synonym Full Names: heat shock 70kDa protein 8
• NCBI Official Symbol: Hspa8
• NCBI Official Synonym Symbols: Hsc70
• NCBI Protein Information: heat shock cognate 71 kDa protein; heat shock protein 8; heat shock protein A8; heat shock 70kD protein 8; Heat shock cognate protein 70
• UniProt Protein Name: Heat shock cognate 71 kDa protein
• UniProt Gene Name: Hspa8
• UniProt Synonym Gene Names: Hsc70; Hsc73
• UniProt Entry Name: HSP7C_RAT

NCBI Description

member of the hsp70 protein; expressed in unstressed cells [RGD, Feb 2006]

Uniprot Description

HSC70: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co- chaperones. Interacts with HSPH1/HSP105. Interacts with IRAK1BP1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with PACRG and TSC2. Interacts with BAG1. Interacts with SV40 VP1. Interacts with DNAJC7. Interacts with HERC5. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation. Constitutively synthesized. Ubiquitous. Belongs to the heat shock protein 70 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Chaperone; Nucleolus; RNA-binding; Heat shock protein

Cellular Component: extracellular space; neuron projection; focal adhesion; protein complex; terminal button; ribonucleoprotein complex; cytosol; spliceosome; synaptic vesicle; membrane; cell soma; cytoplasm; melanosome; plasma membrane; nucleolus; intracellular; nucleus; myelin sheath; ubiquitin ligase complex

Molecular Function: protein binding; enzyme binding; G-protein-coupled receptor binding; heat shock protein binding; ubiquitin protein ligase binding; unfolded protein binding; ATPase activity; ATPase activity, coupled; ADP binding; ATP binding; receptor binding

Biological Process: positive regulation of nuclear mRNA splicing, via spliceosome; protein folding; transcription, DNA-dependent; chaperone cofactor-dependent protein folding; regulation of cell cycle; RNA splicing; protein refolding; negative regulation of transcription, DNA-dependent; mRNA processing