Typical Testing Data/Standard Curve (for reference only)
Mouse Heat shock cognate 71 kDa protein ELISA Kit | Hspa8 elisa kit
Mouse Heat shock cognate 71 kDa protein ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
Uniprot Description
HSC70: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co- chaperones. Interacts with HSPH1/HSP105. Interacts with IRAK1BP1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with PACRG and TSC2. Interacts with BAG1. Interacts with SV40 VP1. Interacts with DNAJC7. Interacts with HERC5. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation. Constitutively synthesized. Ubiquitous. Belongs to the heat shock protein 70 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Chaperone; Nucleolus; Heat shock protein; RNA-binding
Cellular Component: asymmetric synapse; autophagic vacuole; axon; cell soma; cell surface; cytoplasm; cytosol; dendrite; dendritic shaft; dendritic spine; extracellular space; focal adhesion; intermediate filament; intracellular; late endosome; lipid raft; lysosomal membrane; lysosome; membrane; microtubule; myelin sheath; neuron projection; nucleus; perikaryon; perinuclear region of cytoplasm; photoreceptor inner segment; plasma membrane; postsynaptic density; protein complex; ribonucleoprotein complex; spliceosome; synaptic vesicle; terminal button; ubiquitin ligase complex
Molecular Function: A1 adenosine receptor binding; ADP binding; ATP binding; ATPase activity; ATPase activity, coupled; enzyme binding; G-protein-coupled receptor binding; heat shock protein binding; nucleotide binding; peptide binding; phosphatidylserine binding; protein binding; receptor binding; RNA binding; transcription factor binding; ubiquitin protein ligase binding; unfolded protein binding
Biological Process: ATP metabolic process; cellular protein complex disassembly; chaperone cofactor-dependent protein folding; mRNA processing; negative regulation of transcription, DNA-dependent; positive regulation of catalytic activity; positive regulation of nuclear mRNA splicing, via spliceosome; positive regulation of phagocytosis; positive regulation of proteolysis; positive regulation of T cell mediated cytotoxicity; protein amino acid autophosphorylation; protein folding; protein import into nucleus; protein refolding; regulation of cell cycle; regulation of protein stability; regulation of transcription, DNA-dependent; RNA splicing; transcription, DNA-dependent
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Product Notes
The Mouse Hspa8 hspa8 (Catalog #AAA2887007) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2887007 ELISA Kit recognizes Mouse Hspa8. It is sometimes possible for the material contained within the vial of "Heat shock cognate 71 kDa protein, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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