Human myeloid/lymphoid or mixed-lineage leukemia 3 ELISA Kit | MLL3 elisa kit
Human Histone-lysine N-methyltransferase MLL3, MLL3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008]
Uniprot Description
MLL3: a protein methyltransferase that methylates K4 of histone H3. H3K4 methylation represents a specific tag for epigenetic transcriptional activation. Found in a critical region of chromosome 7, which is commonly deleted in malignant myeloid disorders. Partial duplication of the MLL3 gene are found in the juxtacentromeric region of chromosomes 1, 2, 13 and 21. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. MLL3 may be a catalytic subunit of this complex. Contributes to genome-scale circadian transcription. May be involved in leukemogenesis and developmental disorder. Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver. Belongs to the protein lysine methyltransferase family. TRX/MLL subfamily. Three isoforms of the human protein are produced by alternative splicing.
Protein type: Methyltransferase, protein lysine; EC 2.1.1.43; Methyltransferase
Chromosomal Location of Human Ortholog: 7q36.1
Cellular Component: nucleoplasm; histone methyltransferase complex; nucleus
Molecular Function: protein binding; DNA binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific)
Biological Process: establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent; histone H3-K4 methylation
Research Articles on MLL3
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Product Notes
The Human MLL3 kmt2c (Catalog #AAA9321421) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9321421 ELISA Kit recognizes Human MLL3. It is sometimes possible for the material contained within the vial of "myeloid/lymphoid or mixed-lineage leukemia 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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