Tdgf1 blocking peptide

Tdgf1 Blocking Peptide (N-term)

• Gene Names: Tdgf1; CR1; cripto
• Synonyms: Tdgf1; Tdgf1 Blocking Peptide (N-term); Teratocarcinoma-derived growth factor; Cripto growth factor; Epidermal growth factor-like Cripto protein; Cripto; Tdgf1 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 37-50 of HUMAN Tdgf1
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 171

• Cellular Location: Cell membrane; Lipid-anchor, GPI-anchor
• Tissue Location: Expressed at low level in specific organs of the adult animal such as spleen, heart, lung and brain. During gastrulation, expressed in the forming mesoderm. In later stages of the developing heart, expression is restricted to the truncus arteriosus
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Tdgf1 blocking peptide

Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

NCBI and Uniprot Product Information

• NCBI GI #: 1706128
• NCBI GeneID: 21667
• UniProt Accession #: P51865
• Molecular Weight: 18,754 Da
• NCBI Official Full Name: Teratocarcinoma-derived growth factor
• NCBI Official Synonym Full Names: teratocarcinoma-derived growth factor 1
• NCBI Official Symbol: Tdgf1
• NCBI Official Synonym Symbols: CR1; cripto
• NCBI Protein Information: teratocarcinoma-derived growth factor
• UniProt Protein Name: Teratocarcinoma-derived growth factor
• Protein Family: Teratocarcinoma-derived growth factor
• UniProt Gene Name: Tdgf1
• UniProt Synonym Gene Names: Cripto
• UniProt Entry Name: TDGF1_MOUSE

Uniprot Description

TDGF1: Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Interacts with the activin type-1 receptor ACVR1B. Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.

Protein type: Membrane protein, GPI anchor; Motility/polarity/chemotaxis; Membrane protein, peripheral; Cell adhesion; Cell cycle regulation

Cellular Component: apical plasma membrane; cell surface; cytoplasm; extracellular region; extracellular space; extrinsic to plasma membrane; Golgi apparatus; lipid raft; nucleus; perinuclear region of cytoplasm

Molecular Function: coreceptor activity; growth factor activity; protein binding; receptor binding; Wnt-protein binding

Biological Process: activation of MAPK activity; anterior/posterior axis specification; BMP signaling pathway; cardiac muscle cell differentiation; cell differentiation; cell migration during sprouting angiogenesis; determination of anterior/posterior axis, embryo; epidermal growth factor receptor signaling pathway; gastrulation; heart development; in utero embryonic development; morphogenesis of a branching structure; negative regulation of apoptosis; negative regulation of transforming growth factor beta receptor signaling pathway; peptidyl-serine phosphorylation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of fibroblast proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell migration; regulation of signal transduction; vasculogenesis; Wnt receptor signaling pathway through beta-catenin