Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Human A Disintegrin And Metalloprotease 8 Polyclonal Antibody | anti-ADAM8 antibody
Polyclonal Antibody to A Disintegrin And Metalloprotease 8 (ADAM8)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-SFPRMFSDCS QAYLESFLER PQSVCLANAP DLSHLVGGPV CGNLFVERGE QCDCGPPEDC RNRCCNSTTC QLAEGAQCAH GTCCQECKVK PAGELCRPKK DMCDLEEFCD GRHPECPEDA FQENGTPCSG GYCYNGACPT LAQQCQAFWG PGGQAAEESC FSYDILPGCK
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]
Uniprot Description
ADAM8: Possible involvement in extravasation of leukocytes.
Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease
Chromosomal Location of Human Ortholog: 10q26.3
Cellular Component: alpha9-beta1 integrin-ADAM8 complex; cell surface; cytoplasm; dense core granule membrane; integral component of plasma membrane; plasma membrane; podosome; specific granule
Molecular Function: calcium ion binding; cell adhesion molecule binding; metalloendopeptidase activity; metallopeptidase activity; protein binding; protein self-association; serine-type endopeptidase activity; zinc ion binding
Biological Process: angiogenesis; cell morphogenesis; cellular response to hypoxia; extracellular matrix disassembly; inflammatory response; leukocyte migration involved in inflammatory response; lymphocyte chemotaxis; negative regulation of neuron apoptosis; neutrophil degranulation; positive regulation of acute inflammatory response; positive regulation of bone resorption; positive regulation of cell adhesion; positive regulation of eosinophil migration; positive regulation of fibronectin-dependent thymocyte migration; positive regulation of innate immune response; positive regulation of MAP kinase activity; positive regulation of membrane protein ectodomain proteolysis; positive regulation of neutrophil extravasation; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein kinase B signaling; positive regulation of protein processing; positive regulation of protein secretion; positive regulation of T cell differentiation in thymus; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; proteolysis; regulation of cell-cell adhesion
Research Articles on ADAM8
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Product Notes
The ADAM8 adam8 (Catalog #AAA2027736) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to A Disintegrin And Metalloprotease 8 (ADAM8) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's A Disintegrin And Metalloprotease 8 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.2-2ug/mL;1:250-2500 Immunohistochemistry: 5-20ug/mL;1:25-100 Immunocytochemistry: 5-20ug/mL;1:25-100 Optimal working dilutions must be determined by end user. . Researchers should empirically determine the suitability of the ADAM8 adam8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-SFP RMFSDCS QAYLESFLER PQSVCLANAP DLSHLVGGPV CGNLFVERGE QCDCGPPEDC RNRCCNSTTC QLAEGAQCAH GTCCQECKVK PAGELCRPKK DMCDLEEFCD GRHPECPEDA FQENGTPCSG GYCYNGACPT LAQQCQAFWG PGGQAAEESC FSYDILPGCK. It is sometimes possible for the material contained within the vial of "A Disintegrin And Metalloprotease 8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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