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PHAR4 Blocking Peptide | PHACTR4 blocking peptide

PHAR4 Antibody (C-term) Blocking Peptide

Gene Names
PHACTR4; PPP1R124
Synonyms
PHAR4; PHAR4 Antibody (C-term) Blocking Peptide; Phosphatase and actin regulator 4; PHACTR4; PHACTR4 blocking peptide
Ordering
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
702
Cellular Location
Cytoplasm. Cell projection, lamellipodium
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for PHACTR4 blocking peptide
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
7,586 Da
NCBI Official Full Name
Phosphatase and actin regulator 4
NCBI Official Synonym Full Names
phosphatase and actin regulator 4
NCBI Official Symbol
PHACTR4
NCBI Official Synonym Symbols
PPP1R124
NCBI Protein Information
phosphatase and actin regulator 4
UniProt Protein Name
Phosphatase and actin regulator 4
UniProt Gene Name
PHACTR4
UniProt Entry Name
PHAR4_HUMAN

NCBI Description

This gene encodes a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

PHACTR4: a protein of unknown function. Contains three RPEL repeats named after four conserved amino acids it contains.

Protein type: Phosphatase; Actin-binding

Chromosomal Location of Human Ortholog: 1p35.3

Cellular Component: lamellipodium

Molecular Function: actin binding; protein phosphatase 1 binding

Biological Process: actin cytoskeleton organization and biogenesis; enteric nervous system development; neural crest cell migration; neural tube closure; positive regulation of catalytic activity; regulation of cell cycle; Rho protein signal transduction

Research Articles on PHACTR4

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Product Notes

The PHACTR4 phactr4 (Catalog #AAA9228472) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PHAR4, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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