anti-Human, Rat LT-alpha (Lymphotoxin-alpha) Antibody | anti-LT-alpha antibody

LT-alpha (Lymphotoxin-alpha) Antibody

Cat. Num. AAA850579

• Gene Names: LTA; LT; TNFB; TNFSF1; TNLG1E
• Reactivity: Human, Rat
• Applications: ELISA, Western Blot
• Synonyms: LT-alpha (Lymphotoxin-alpha); LT-alpha (Lymphotoxin-alpha) Antibody; anti-LT-alpha antibody

• Reactivity: Human, Rat
• Specificity: This antibody is produced by immunizing mouse with a synthetic peptide (KLH-coupled) corresponding to LT-alpha.
• Form/Format: In 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol.
• Sequence Length: 205

• Applicable Applications for anti-LT-alpha antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: ELISA: 1:10,000; WB: 1:500
• Preservative: 0.05% Sodium Azide.
• Cellular Localization: Secretory Protein
• Positive Control: Recombinant LT-alpha
• Preparation and Storage: Store at +4 degree C after thawing. Aliquot store at-20 degree C or-80 degree C. Avoid repeated freeze/thaw cycles.

Testing Data

Related Product Information for anti-LT-alpha antibody

Lymphotoxin-alpha (LTA), a member of the tumor necrosis factor (TNF) family of cytokines, was initially isolated on the basis of an anti-tumor activity. LTA plays a key role in communication between lymphocytes and stromal cells, thereby eliciting cytotoxic effects on cancer cells. It induces the expression of vascular cell-adhesion molecule 1 (VCAM1) on vascular endothelial cells and recruits natural killer (NK) cells to parenchymal organs and tumor lesions.

References

1. Bell G.I., Pictet R.L., Rutter W.J., Cordell B., Tischer E., Goodman H.M.; "Sequence of the human insulin gene."; Nature 284:26-32(1980). 2. Nicol D.S.H.W., Smith L.F.; "Amino-acid sequence of human insulin."; Nature 187:483-485(1960). 3. Chang X., Joergensen A.M., Bardrum P., Led J.J.; "Solution structures of the R6 human insulin hexamer."; Biochemistry 36:9409-9422(1997).

NCBI and Uniprot Product Information

• NCBI GI #: 6806893
• NCBI GeneID: 4049
• NCBI Accession #: NP_000586.2
• NCBI GenBank Nucleotide #: NM_000595.3
• UniProt Accession #: P01374; Q8N4C3; Q9UKS8
• Molecular Weight: 18kDa
• NCBI Official Full Name: lymphotoxin-alpha
• NCBI Official Synonym Full Names: lymphotoxin alpha
• NCBI Official Symbol: LTA
• NCBI Official Synonym Symbols: LT; TNFB; TNFSF1; TNLG1E
• NCBI Protein Information: lymphotoxin-alpha
• UniProt Protein Name: Lymphotoxin-alpha
• UniProt Gene Name: LTA
• UniProt Synonym Gene Names: TNFB; TNFSF1; LT-alpha

NCBI Description

The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

Uniprot Description

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.