YES1 blocking peptide

YES1 Antibody (N-term) Blocking peptide

• Gene Names: YES1; Yes; c-yes; HsT441; P61-YES
• Synonyms: YES1; YES1 Antibody (N-term) Blocking peptide; Tyrosine-protein kinase Yes; Proto-oncogene c-Yes; p61-Yes; YES; YES1 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 11~25 of human YES.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 543

• Cellular Location: Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol Note: Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway
• Tissue Location: Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for YES1 blocking peptide

Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.

NCBI and Uniprot Product Information

• NCBI GI #: 125870
• NCBI GeneID: 7525
• UniProt Accession #: P07947; A6NLB3; D3DUH1
• Molecular Weight: 60,801 Da
• NCBI Official Full Name: Tyrosine-protein kinase Yes
• NCBI Official Synonym Full Names: YES proto-oncogene 1, Src family tyrosine kinase
• NCBI Official Symbol: YES1
• NCBI Official Synonym Symbols: Yes; c-yes; HsT441; P61-YES
• NCBI Protein Information: tyrosine-protein kinase Yes
• UniProt Protein Name: Tyrosine-protein kinase Yes
• Protein Family: Tyrosine-protein kinase
• UniProt Gene Name: YES1
• UniProt Synonym Gene Names: YES
• UniProt Entry Name: YES_HUMAN

NCBI Description

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

Uniprot Description

Yes: a proto-oncogenic cytosolic tyrosine kinase of the Src family. Expressed at high levels in adult neurons, spermatozoa, platelets, and epithelial cells.

Protein type: EC 2.7.10.2; Oncoprotein; Kinase, protein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; TK group; Src family

Chromosomal Location of Human Ortholog: 18p11.31-p11.21

Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; Golgi apparatus; plasma membrane

Molecular Function: enzyme binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding

Biological Process: cell differentiation; ephrin receptor signaling pathway; innate immune response; leukocyte migration; protein modification process; regulation of cell proliferation; regulation of vascular permeability; T cell costimulation; transmembrane receptor protein tyrosine kinase signaling pathway