DPT blocking peptide

DPT Antibody (Center) Blocking Peptide

• Gene Names: DPT; TRAMP
• Synonyms: DPT; DPT Antibody (Center) Blocking Peptide; Dermatopontin; Tyrosine-rich acidic matrix protein; TRAMP; DPT blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of human DPT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 201

• Cellular Location: Secreted, extracellular space, extracellular matrix
• Tissue Location: Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for DPT blocking peptide

Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 27151769
• NCBI GeneID: 1805
• UniProt Accession #: Q07507; Q8N4R2; Q9UIX8; A8K981
• Molecular Weight: 24,005 Da
• NCBI Official Full Name: Dermatopontin
• NCBI Official Synonym Full Names: dermatopontin
• NCBI Official Symbol: DPT
• NCBI Official Synonym Symbols: TRAMP
• NCBI Protein Information: dermatopontin
• UniProt Protein Name: Dermatopontin
• Protein Family: Dermatopontin
• UniProt Gene Name: DPT
• UniProt Synonym Gene Names: TRAMP
• UniProt Entry Name: DERM_HUMAN

NCBI Description

Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin. [provided by RefSeq, Jul 2008]

Uniprot Description

DPT: Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation. Belongs to the dermatopontin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q12-q23

Cellular Component: extracellular matrix; extracellular space