ERO1LB blocking peptide

ERO1LB Antibody (C-term) Blocking peptide

• Gene Names: ERO1B; ERO1LB; Ero1beta
• Synonyms: ERO1LB; ERO1LB Antibody (C-term) Blocking peptide; ERO1-like protein beta; ERO1-L-beta; 184-; Endoplasmic reticulum oxidoreductin-1-like protein B; Oxidoreductin-1-L-beta; ERO1LB blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 467

• Cellular Location: Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Note: The association with ERP44 may be essential for its retention in the endoplasmic reticulum
• Tissue Location: Highly expressed in the digestive tract, including the duodenum and lower digestive tract. In the stomach, highly expressed in enzyme-producing chief cells (at protein level). In the pancreas, expressed in islets of Langerhans and, at lower levels, in enzyme-secreting cells (at protein level) Detected at low level in many other tissues
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ERO1LB blocking peptide

Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate), as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (

NCBI and Uniprot Product Information

• NCBI GI #: 116241353
• NCBI GeneID: 56605
• UniProt Accession #: Q86YB8; Q5T1H4; Q8IZ11; Q9NR62; B4DF57
• Molecular Weight: 16,096 Da
• NCBI Official Full Name: ERO1-like protein beta
• NCBI Official Synonym Full Names: endoplasmic reticulum oxidoreductase 1 beta
• NCBI Official Symbol: ERO1B
• NCBI Official Synonym Symbols: ERO1LB; Ero1beta
• NCBI Protein Information: ERO1-like protein beta
• UniProt Protein Name: ERO1-like protein beta
• UniProt Gene Name: ERO1B
• UniProt Synonym Gene Names: ERO1-L-beta
• UniProt Entry Name: ERO1B_HUMAN

Uniprot Description

ERO1LB: Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress. Belongs to the EROs family.

Protein type: Endoplasmic reticulum; EC 1.8.4.-; Oxidoreductase

Chromosomal Location of Human Ortholog: 1q42.2-q43

Cellular Component: endoplasmic reticulum

Molecular Function: protein binding

Biological Process: protein folding