CNO6L Blocking Peptide | CNOT6L blocking peptide

CNO6L Antibody (C-term) Blocking peptide

• Gene Names: CNOT6L; CCR4b
• Synonyms: CNO6L; CNO6L Antibody (C-term) Blocking peptide; CCR4-NOT transcription complex subunit 6-like; Carbon catabolite repressor protein 4 homolog B; CNOT6L; CCR4B; CNOT6L blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 555

• Cellular Location: Cytoplasm. Nucleus.
• Tissue Location: Highly expressed in placenta, skeletal muscle, pancreas, testis and leukocytes. Weakly expressed in heart, spleen and thymus.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CNOT6L blocking peptide

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence.

NCBI and Uniprot Product Information

• NCBI GI #: 166216089
• NCBI GeneID: 246175
• UniProt Accession #: Q96LI5; Q9UF92
• Molecular Weight: 53,891 Da
• NCBI Official Full Name: CCR4-NOT transcription complex subunit 6-like
• NCBI Official Synonym Full Names: CCR4-NOT transcription complex subunit 6 like
• NCBI Official Symbol: CNOT6L
• NCBI Official Synonym Symbols: CCR4b
• NCBI Protein Information: CCR4-NOT transcription complex subunit 6-like
• UniProt Protein Name: CCR4-NOT transcription complex subunit 6-like
• Protein Family: CCR4-NOT transcription complex
• UniProt Gene Name: CNOT6L
• UniProt Synonym Gene Names: CCR4B
• UniProt Entry Name: CNO6L_HUMAN

Uniprot Description

CNOT6L: Plays a role in the deadenylation of mRNAs in the cytoplasm. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation- dependent degradation of CDKN1B mRNA. Belongs to the CCR4/nocturin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; EC 3.1.13.4

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: CCR4-NOT complex; cytoplasm; cytosol; nucleus

Molecular Function: poly(A)-specific ribonuclease activity; protein binding

Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; poly(A) tail shortening; positive regulation of cell proliferation