NCAPG blocking peptide

NCAPG Antibody (N-term) Blocking Peptide

• Gene Names: NCAPG; CAPG; CHCG; YCG1; NY-MEL-3
• Synonyms: NCAPG; NCAPG Antibody (N-term) Blocking Peptide; Condensin complex subunit 3; Chromosome-associated protein G; Condensin subunit CAP-G; hCAP-G; Melanoma antigen NY-MEL-3; Non-SMC condensin I complex subunit G; XCAP-G homolog; CAPG; NYMEL3; NCAPG blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1015

• Cellular Location: Nucleus. Cytoplasm. Chromosome. Note: In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation Dissociation from chromosomes is observed in late telophase
• Tissue Location: Highly expressed in testis.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NCAPG blocking peptide

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

NCBI and Uniprot Product Information

• NCBI GI #: 30172941
• NCBI GeneID: 64151
• UniProt Accession #: Q9BPX3; Q3MJE0; Q96SV9; Q9BUR3; Q9BVY1; Q9H914; Q9H9Z6; Q9HBI9
• Molecular Weight: 114,334 Da
• NCBI Official Full Name: Condensin complex subunit 3
• NCBI Official Synonym Full Names: non-SMC condensin I complex subunit G
• NCBI Official Symbol: NCAPG
• NCBI Official Synonym Symbols: CAPG; CHCG; YCG1; NY-MEL-3
• NCBI Protein Information: condensin complex subunit 3
• UniProt Protein Name: Condensin complex subunit 3
• UniProt Gene Name: NCAPG
• UniProt Synonym Gene Names: CAPG; NYMEL3; hCAP-G
• UniProt Entry Name: CND3_HUMAN

NCBI Description

This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Uniprot Description

NCAPG: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Belongs to the CND3 (condensin subunit 3) family.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 4p15.33

Cellular Component: actin cytoskeleton; centrosome; condensin complex; cytoplasm; cytosol; membrane

Molecular Function: protein binding

Biological Process: mitotic chromosome condensation