Western Blot (WB)
(SEC62 Antibody (N-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the SEC62 antibody detected the SEC62 protein (arrow).)
Rabbit SEC62 Polyclonal Antibody | anti-SEC62 antibody
SEC62 Antibody (N-term)
Western Blot (WB)
(SEC62 Antibody (N-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the SEC62 antibody detected the SEC62 protein (arrow).)
Western Blot (WB)
(SEC62 Antibody (N-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the SEC62 antibody detected the SEC62 protein (arrow).)
Immunohistochemistry (IHC)
(SEC62 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SEC62 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(SEC62 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SEC62 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
translocation apparatus of the endoplasmic reticulum (ER) membrane.
The protein encoded by this gene and SEC63 protein are found to be
associated with ribosome-free SEC61 complex. It is speculated that
Sec61-Sec62-Sec63 may perform post-translational protein
translocation into the ER. The Sec61-Sec62-Sec63 complex might also
perform the backward transport of ER proteins that are subject to
the ubiquitin-proteasome-dependent degradation pathway. The encoded
protein is an integral membrane protein located in the rough ER.
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Lim, J., et al. Cell 125(4):801-814(2006)
Jung, V., et al. Mol. Cancer Res. 4(3):169-176(2006)
Meyer, H.A., et al. J. Biol. Chem. 275(19):14550-14557(2000)
NCBI and Uniprot Product Information
NCBI Description
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Uniprot Description
SEC62: a multi-pass membrane protein and component of the Sec61 complex of the rough endoplasmic reticulum membrane. The Sec61 complex may perform post-translational protein translocation into the ER and backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Endoplasmic reticulum; Channel, misc.
Chromosomal Location of Human Ortholog: 3q26.2
Cellular Component: intermediate filament cytoskeleton; endoplasmic reticulum membrane; membrane; rough endoplasmic reticulum; endoplasmic reticulum; integral to membrane
Molecular Function: receptor activity; protein transporter activity
Biological Process: posttranslational protein targeting to membrane; cotranslational protein targeting to membrane
Research Articles on SEC62
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Product Notes
The SEC62 sec62 (Catalog #AAA9211353) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-30. The SEC62 Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's SEC62 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the SEC62 sec62 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SEC62, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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