Structure
MAK683, inhibitor
MAK683
Purity
98.00%
Synonyms
MAK683; inhibitor
Purity/Purification
98.00%
Form/Format
Solid. Powder
Solubility
DMSO: 50mg/mL (132.84mM) Need ultrasonic
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C20H17FN6O
SMILES
Cc1ncccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
CAS Number
1951408-58-4
Target & IC50
EED Alphascreen: ic50 59nM
LC-MS: ic50 89nM
ELISA: ic50 26nM
LC-MS: ic50 89nM
ELISA: ic50 26nM
In Vitro
After treatment,14 days, MAK683 has antiproliferative activities in B cell lymphoma cell KARPAS422 (IC50: 30nM) [1].
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
-80 degree C for 2 years in solvent
Structure
Structure
Related Product Information for MAK683, inhibitor
MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26nM in EED Alphascreen binding, LC-MS and ELISA assay).
References
Chan, Ho Man, et al. TRIAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF. US20160176882 A1.
Chan, Ho Man, et al. TRIAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF. US20160176882 A1.
Huang D, et al. Binding Modes of Small-Molecule Inhibitors to the EED Pocket of PRCChemphyschem. 2020 Feb 4;21(3):263-271.
Huang D, et al. Binding Modes of Small-Molecule Inhibitors to the EED Pocket of PRC2. Chemphyschem. 2020 Feb 4;21(3):263-271.
Chan, Ho Man, et al. TRIAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF. US20160176882 A1.
Huang D, et al. Binding Modes of Small-Molecule Inhibitors to the EED Pocket of PRCChemphyschem. 2020 Feb 4;21(3):263-271.
Huang D, et al. Binding Modes of Small-Molecule Inhibitors to the EED Pocket of PRC2. Chemphyschem. 2020 Feb 4;21(3):263-271.
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Product Notes
The MAK683 (Catalog #AAA5754818) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MAK683, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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