Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Rat Disks large homolog 3 (DLG3) Standard Curve.)
Rat Disks Large Homolog 3 (DLG3) ELISA Kit | DLG3 elisa kit
Rat Disks Large Homolog 3 (DLG3) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Rat Disks large homolog 3 (DLG3) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Rat Disks large homolog 3 (DLG3) Standard Curve.)
Background: DLG3 is a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described. The predicted 817-amino acid protein contains the 3 DHR segments, central SH3 motif, and C-terminal guanylate kinase domain characteristic of MAGUK proteins. NEDLG shares 75% and 60% protein sequence identity with DLG1 and Drosophila dlg, respectively. NEDLG is highly expressed in neuronal and endocrine tissues.
NCBI and Uniprot Product Information
NCBI Description
human homolog is a protein with guanylate kinase activity; involved in synaptogenesis and cell proliferation [RGD, Feb 2006]
Uniprot Description
DLG3: Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. Interacts through its PDZ domains with NETO1, GRIN2B and SYNGAP1. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4. Interacts through its PDZ domains with APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts with FRMPD4 (via C-terminus). Interacts with LRFN1, LRFN2 and LRFN4. Belongs to the MAGUK family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: Xq22
Cellular Component: basolateral plasma membrane; cell soma; cytoplasm; dendritic shaft; extracellular space; growth cone; intercellular junction; ionotropic glutamate receptor complex; plasma membrane; postsynaptic density; postsynaptic membrane; synapse; tight junction
Molecular Function: guanylate kinase activity; ionotropic glutamate receptor binding; kinase binding; PDZ domain binding; phosphatase binding; protein binding; protein C-terminus binding; protein domain specific binding; protein phosphatase binding; ubiquitin protein ligase binding
Biological Process: establishment and/or maintenance of epithelial cell polarity; establishment of planar polarity; nervous system development; receptor clustering; synaptic transmission
Research Articles on DLG3
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Product Notes
The Rat DLG3 dlg3 (Catalog #AAA9712424) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9712424 ELISA Kit recognizes Rat DLG3. It is sometimes possible for the material contained within the vial of "Disks Large Homolog 3 (DLG3), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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