Western Blot (WB)
(CYP4V2 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the CYP4V2 antibody detected the CYP4V2 protein (arrow).)
Rabbit anti-Human CYP4V2 Polyclonal Antibody | anti-CYP4V2 antibody
CYP4V2 Antibody (C-term)
Western Blot (WB)
(CYP4V2 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the CYP4V2 antibody detected the CYP4V2 protein (arrow).)
Western Blot (WB)
(CYP4V2 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the CYP4V2 antibody detected the CYP4V2 protein (arrow).)
hemethiolate protein superfamily which are involved in oxidizing
various substrates in the metabolic pathway. It is implicated in
the metabolism of fatty acid precursors into n-3 polyunsaturated
fatty acids.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Pelak, K., et al. J. Infect. Dis. 201(8):1141-1149(2010)
Nakano, M., et al. Drug Metab. Dispos. 37(11):2119-2122(2009)
Li, Y., et al. J. Thromb. Haemost. 7(11):1802-1808(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the cytochrome P450 hemethiolate protein superfamily which are involved in oxidizing various substrates in the metabolic pathway. It is implicated in the metabolism of fatty acid precursors into n-3 polyunsaturated fatty acids. Mutations in this gene result in Bietti crystalline corneoretinal dystrophy. [provided by RefSeq, Jul 2008]
Uniprot Description
CYP4V2: Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12). May have a role in fatty acid and steroid metabolism in the eye. Defects in CYP4V2 are a cause of Bietti crystalline corneoretinal dystrophy (BCD). BCD is an autosomal recessive retinal dystrophy characterized by multiple glistening intraretinal crystals scattered over the fundus, a characteristic degeneration of the retina, and sclerosis of the choroidal vessels, ultimately resulting in progressive night blindness and constriction of the visual field. Most cases have similar crystals at the corneoscleral limbus. Clinically, BCD is progressive. Patients develop decreased vision, nyctalopia, and paracentral scotomata between the 2nd and 4th decade of life. Later, patients develop peripheral visual field loss and marked visual impairment, usually progressing to legal blindness by the 5th or 6th decade of life. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.13.199; Oxidoreductase; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q35.2
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; iron ion binding; heme binding; monooxygenase activity
Biological Process: visual perception; response to stimulus; fatty acid omega-oxidation
Disease: Bietti Crystalline Corneoretinal Dystrophy
Research Articles on CYP4V2
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Product Notes
The CYP4V2 cyp4v2 (Catalog #AAA9208672) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 496-525. The CYP4V2 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CYP4V2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the CYP4V2 cyp4v2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CYP4V2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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