Testing Data
Sorafenib, Inhibitor
Sorafenib (Nexavar)
Purity
>99%
Synonyms
Sorafenib; Sorafenib (Nexavar); inhibitor
Purity/Purification
>99%
Solubility
DMSO >=127mg/mL - Water <1mg/mL - Ethanol <1mg/mL
Formula
C21H16ClF3N4O3.C7H8O3S
CAS Number
475207-59-1
Preparation and Storage
Store at-20 degree C 2 years.
Testing Data
Testing Data
Related Product Information for Sorafenib, inhibitor
Sorafenib (Nexavar) is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF. It does not significantly inhibit MEK-1 or ERK-1 activity (IC50, >10 uM). MDA-MB-231 human breast carcinoma cells were the most sensitive cell line identified for inhibition of the MAPK pathway by BAY 43-9006 (IC50, 90nM). Several other cell lines responded to BAY 43-9006 treatment, including the LOX human melanoma (IC50, 880 nM), BxPC3 human pancreatic (IC50, 1200 nM), and the HCT 116, DLD-1, and Colo-205 human colon carcinoma cells (IC50s ranging between 2000 and 4000 nmol/L). [1][2]It interacts synergistically with bortezomib to induce apoptosis in a broad spectrum of neoplastic cell lines and show an important role for the Akt and JNK pathways in mediating synergism. [3]
Product Categories/Family for Sorafenib, inhibitor
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Product Notes
The Sorafenib (Catalog #AAA8506152) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Sorafenib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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