Structure
666-15 Biochemical
666-15
Purity
0.9865
Synonyms
666-15; 3- (3-aminopropoxy)-N-[2-[3-[ (4-chloro-2-hydroxyphenyl) carbamoyl]naphthalen-2-yl]oxyethyl]naphthalene-2-carboxamide; hydrochloride; 3- (3-Aminopropoxy)-N- (2- ( (3- ( (4-chloro-2-hydroxyphenyl) carbamoyl) naphthalen-2-yl) oxy) ethyl)-2-naphthamide hydrochloride; CREB 666-15; CREB Inhibitor; CBP-CREB Interaction Inhibitor II; Compound 3i; 666-15 biochemical
Purity/Purification
0.9865
Form/Format
Solid
Solubility
~30 mg/ml in DMSO
Molecular Formula
C??H??Cl?N?O?
CAS Number
1433286-70-4
PubChem CID
71566396
SMILES
C1=CC=C2C=C (C (=CC2=C1)C (=O)NCCOC3=CC4=CC=CC=C4C=C3C (=O)NC5=C (C=C (C=C5)Cl)O)OCCCN.Cl
InChi
InChI=1S/C33H30ClN3O5.ClH/c34-25-10-11-28 (29 (38)20-25)37-33 (40)27-17-22-7-2-4-9-24 (22)19-31 (27)42-15-13-36-32 (39)26-16-21-6-1-3-8-23 (21)18-30 (26)41-14-5-12-35;/h1-4,6-11,16-20,38H,5,12-15,35H2, (H,36,39)(H,37,40);1H
InChi Key
LELLCPHHYHLWBH-UHFFFAOYSA-N
Preparation and Storage
Store at -20 degree C
Shelf life: ~36 months
Shelf life: ~36 months
Structure
Structure
Related Product Information for 666-15 biochemical
666-15 is a potent and selective inhibitor of cyclic adenosine monophosphate response element binding protein (CREB) -mediated gene transcription with an IC50 of 81 nM. The IC50 values for inhibiting the growth of A549, MCF-7, MDA-MB-231, MDA-MB-468 cell lines are 0.47 uM, 0.31 uM, 0.073 uM, 0.046 uM respectively. It is a weak inhibitor of CREB-CBP (CREB-binding protein) interaction with an IC50 of 18.27 uM. Intraperitoneal injection of 666-15 at 10 mg/kg/day, 5 days per week for 5 weeks suppresses tumor growth in an in vivo MDA-MB-468 xenograft model.
Product Categories/Family for 666-15 biochemical
References
https://pubchem.ncbi.nlm.nih.gov/compound/71566396
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Product Notes
The 666-15 (Catalog #AAA849065) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "666-15, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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