Structure
CA-074 Biochemical
CA-074
Purity
0.98
Synonyms
CA-074; (2S)-1-[ (2S; 3S)-3-methyl-2-[[ (2S; 3S)-3- (propylcarbamoyl) oxirane-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carboxylic acid; Cathepsin B Inhibitor III; N-{[ (2S; 3S)-3- (propylcarbamoyl) oxiran-2-yl]carbonyl}-L-isoleucyl-L-proline; CA-074 biochemical
Purity/Purification
0.98
Form/Format
Solid
Solubility
~8 mg/ml in DMSO
Molecular Formula
C??H??N?O?
CAS Number
134448-10-5
PubChem CID
9821383
SMILES
CCCNC (=O)C1C (O1)C (=O)NC (C (C)CC)C (=O)N2CCCC2C (=O)O
InChi
InChI=1S/C18H29N3O6/c1-4-8-19-15 (22)13-14 (27-13)16 (23)20-12 (10 (3)5-2)17 (24)21-9-6-7-11 (21)18 (25)26/h10-14H,4-9H2,1-3H3, (H,19,22)(H,20,23)(H,25,26)/t10-,11-,12-,13-,14-/m0/s1
InChi Key
ZEZGJKSEBRELAS-PEDHHIEDSA-N
Preparation and Storage
Store at -20 degree C
Shelf life: ~36 months
Shelf life: ~36 months
Structure
Structure
Related Product Information for CA-074 biochemical
CA-074 is an epoxysuccinyl peptide inhibitor of cathepsin B. It selectively inhibits cathepsin B with an IC50 of 2.24 nM over other cysteine proteinases such as cathepsins L and H, and calpains. It inhibits cathepsins H, L and calpain with IC50 values of 172 uM, 420 uM and 200 uM. Intraperitoneal administration (50 mg/kg) of CA-074 reduces metastasis in 4T1.2 mouse xenograft model. It reduces mercury induced expression of inflammatory cytokines in mice.
Product Categories/Family for CA-074 biochemical
References
https://pubchem.ncbi.nlm.nih.gov/compound/9821383
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Product Notes
The CA-074 (Catalog #AAA849066) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CA-074, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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