Typical Testing Data/Standard Curve
Mouse CD304 ELISA Kit | NRP1 elisa kit
Mouse CD304 ELISA Kit
Typical Testing Data/Standard Curve
Typical Testing Data/Standard Curve
Background/Introduction: NRP1 (Neuropilin 1) also known as NP1, NRP, BDCA4 or VEGF165R, is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF) and semaphorin family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion. By somatic cell hybrid analysis, the NRP1 gene was mapped to chromosome 10. NRP1 bounds PGF1 with lower affinity. NRP1-mediated interactions are a necessary element in the initiation of the primary immune response and offer another example, like that of agrin, of a molecule shared by neurologic and immunologic synapses. After T-cell contact with DC, T-cell NRP1 colocalized with CD3 in the immunologic synapse and, sometimes, also at the opposite pole of the T cell. Soluble NRP1 interacts in a homophilic fashion with NRP1 on both DC and T cells, and this binding can be inhibited by blocking antibodies to NRP1. Furthermore, selective NRP1 inhibition in this model suppressed neovascular formation substantially.
NCBI and Uniprot Product Information
Uniprot Description
NRP1: The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. Homodimer, and heterodimer with NRP2. Interacts with FER. Binds PLXNB1. The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules. Belongs to the neuropilin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Cellular Component: axon; cell soma; cell surface; cytosol; early endosome; extracellular space; focal adhesion; growth cone; integral to membrane; membrane; neurofilament; plasma membrane
Molecular Function: growth factor binding; heparin binding; metal ion binding; protein binding; semaphorin receptor activity; vascular endothelial growth factor receptor activity
Biological Process: angiogenesis; artery morphogenesis; axon extension involved in axon guidance; axon guidance; axonal fasciculation; branchiomotor neuron axon guidance; cell differentiation; cell migration; cell migration during sprouting angiogenesis; dendrite development; facial nerve structural organization; gonadotrophin-releasing hormone neuronal migration to the hypothalamus; heart development; hepatocyte growth factor receptor signaling pathway; motor axon guidance; multicellular organismal development; negative regulation of axon extension; negative regulation of axon extension involved in axon guidance; negative regulation of neuron apoptosis; nerve development; nervous system development; neuron development; neuron migration; organ morphogenesis; otic placode formation; patterning of blood vessels; platelet-derived growth factor receptor signaling pathway; positive chemotaxis; positive regulation of axon extension involved in axon guidance; positive regulation of peptidyl-tyrosine phosphorylation; regulation of axon extension involved in axon guidance; retinal ganglion cell axon guidance; sprouting angiogenesis; sympathetic nervous system development; trigeminal nerve morphogenesis; trigeminal nerve structural organization; vascular endothelial growth factor receptor signaling pathway; vestibulocochlear nerve structural organization
Research Articles on NRP1
Similar Products
Product Notes
The Mouse NRP1 nrp1 (Catalog #AAA8244566) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA8244566 ELISA Kit recognizes Mouse NRP1. AAA Biotech's CD304 can be used in a range of immunoassay formats including, but not limited to, Sandwich ELISA (EIA). Researchers should empirically determine the suitability of the NRP1 nrp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD304, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
