Testing Data
anti-Mouse Neuropilin-1 Antibody | anti-Nrp1 antibody
Neuropilin-1 Antibody
Gene Names
Nrp1; Nrp; NP-1; Npn1; NPN-1; C530029I03
Reactivity
Mouse
Applications
Western Blot, Immunocytochemistry
Synonyms
Neuropilin-1; Neuropilin-1 Antibody; anti-Nrp1 antibody
Reactivity
Mouse
Clone Number
10-D9
Specificity
This antibody is produced by immunizing mouse with recombinant protein Neuropilin-1.
Form/Format
In 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol.
Sequence Length
923
Applicable Applications for anti-Nrp1 antibody
Western Blot (WB), Immunocytochemistry (ICC)
Application Notes
WB: 1:1,000~1:2,000
ICC: 1:100~1:200
ICC: 1:100~1:200
Preservative
0.05% Sodium Azide.
Cellular Localization
Cell Membrane; Secretory Protein
Positive Control
Recombinant protein
Preparation and Storage
Store at +4 degree C after thawing. Aliquot store at-20 degree C or-80 degree C. Avoid repeated freeze/thaw cycles.
Testing Data
Testing Data
Related Product Information for anti-Nrp1 antibody
Neuropilin-1 is a single-pass type I membrane protein, which has two isoforms. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. The soluble isoform 2 binds VEGF-165 (vascular endothelial growth factor165) and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. Its expression has an averse effect on blood vessel number and integrity.
Product Categories/Family for anti-Nrp1 antibody
References
1. "Neuropilin-2 and neuropilin-1 are receptors for the 165-amino acid form of vascular endothelial growth factor (VEGF) and of placenta growth factor-2, but only neuropilin-2 functions as a receptor for the 145-amino acid form of VEGF."Gluzman-Poltorak Z., Cohen T., Herzog Y., Neufeld G.J. Biol. Chem. 275:18040-18045(2000). 2. "Neuropilin is a receptor for the axonal chemorepellent semaphorin III."He Z., Tessier-Lavigne M.Cell 90:739-751(1997).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
47kDa
NCBI Official Full Name
neuropilin-1 isoform 1
NCBI Official Synonym Full Names
neuropilin 1
NCBI Official Symbol
Nrp1
NCBI Official Synonym Symbols
Nrp; NP-1; Npn1; NPN-1; C530029I03
NCBI Protein Information
neuropilin-1
UniProt Protein Name
Neuropilin-1
Protein Family
UniProt Gene Name
Nrp1
UniProt Synonym Gene Names
Nrp
Uniprot Description
Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed:26503042).
Research Articles on Nrp1
Similar Products
Product Notes
The Nrp1 nrp1 (Catalog #AAA850768) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Neuropilin-1 Antibody reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Neuropilin-1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC). WB: 1:1,000~1:2,000 ICC: 1:100~1:200. Researchers should empirically determine the suitability of the Nrp1 nrp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Neuropilin-1, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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