Rabbit anti-Mouse MDC Polyclonal Antibody | anti-CCL22 antibody

Anti-MDC Antibody, Rabbit Polyclonal

Cat. Num. AAA8112350

• Gene Names: Ccl22; MDC; DCBCK; ABCD-1; Scya22
• Reactivity: Mouse
• Applications: ELISA
• Purity: Protein A
• Synonyms: MDC; Polyclonal Antibody; Anti-MDC Antibody; Rabbit Polyclonal; CCL22/MDC Antibody; Rabbit PAb; chemokine (C-C motif) ligand 22; Anti-ABCD-1 Antibody; Anti-DCBCK Antibody; Anti-Scya22 Antibody; anti-CCL22 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Mouse CCL22/MDC
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-CCL22 antibody: ELISA (EIA)
• Application Notes: ELISA: 1:1000-1:2000
• Immunogen: Recombinant Mouse CCL22/MDC Protein
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with purified, recombinant Mouse CCL22/MDC (rM CCL22/MDC). Total IgG was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CCL22 antibody

Chemokine (C-C motif) ligand 22(ABCD-1/CCL22)is a kind of CC chemokine which is a family of secreted proteins involved in immunoregulatory and inflammatory processes. The cytokine displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. This ABCD-1/CCL22 chemokine binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated/effector T lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. ABCD-1/CCL22 is highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus, and in Langerhans' cell histiocytosis and atopic dermatitis but not in dermatopathic lymphadenopathy. This chemokine is also found in lymph node, appendix, activated monocytes, resting and activated macrophages. This protein is lower expressed in lung and spleen and very weekly expressed in small intestine.

References

Vulcano M, et al. (2001) Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo. Eur J Immunol. 31(3): 812-22.Kwon DJ, et al. (2011) Casuarinin suppresses TARC/CCL17 and MDC/CCL22 production via blockade of NF-?B and STAT1 activation in HaCaT cells. Biochem Biophys Res Commun. 417(4):1254-9.Hirota T, et al. (2011) Variants of C-C motif chemokine 22 (CCL22) are associated with susceptibility to atopic dermatitis: case-control studies. PLoS One. 6(11):e26987.

NCBI and Uniprot Product Information

• NCBI GI #: 6677879
• NCBI GeneID: 20299
• NCBI Accession #: NP_033163.1
• NCBI GenBank Nucleotide #: NM_009137.2
• UniProt Accession #: O88430
• Molecular Weight: 10,302 Da
• NCBI Official Full Name: C-C motif chemokine 22
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 22
• NCBI Official Symbol: Ccl22
• NCBI Official Synonym Symbols: MDC; DCBCK; ABCD-1; Scya22
• NCBI Protein Information: C-C motif chemokine 22; CC chemokine ABCD-1; SMALL INDUCIBLE CYTOKINE A22 PRECURSOR (CC CHEMOKINE ABCD-1) (ACTIVATED B AND DENDRITIC CELL-DERIVED); activated B and dendritic cell-derived; dendritic cell and B cell derived chemokine; small inducible cytoki
• UniProt Protein Name: C-C motif chemokine 22
• Protein Family: C-C motif chemokine
• UniProt Gene Name: Ccl22
• UniProt Synonym Gene Names: Abcd1; Scya22
• UniProt Entry Name: CCL22_MOUSE

Uniprot Description

CCL22: May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted; Motility/polarity/chemotaxis; Chemokine; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity; cytokine activity

Biological Process: immune response; inflammatory response; chemotaxis