Rabbit anti-Mouse LAIR1 Polyclonal Antibody | anti-LAIR1 antibody

Anti-LAIR1 Antibody, Rabbit Polyclonal

Cat. Num. AAA8112263

• Gene Names: Lair1; Lair-1; BB115266; D7Bwg0421e; 5133400O11Rik
• Reactivity: Mouse
• Applications: ELISA
• Purity: Protein A
• Synonyms: LAIR1; Polyclonal Antibody; Anti-LAIR1 Antibody; Rabbit Polyclonal; LAIR1 Antibody; Rabbit PAb; leukocyte-associated immunoglobulin-like receptor 1; Anti-5133400O11Rik Antibody; Anti-BB115266 Antibody; Anti-D7Bwg0421e Antibody; Anti-Lair-1 Antibody; anti-LAIR1 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Mouse LAIR1
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-LAIR1 antibody: ELISA (EIA)
• Application Notes: ELISA: 1:1000-1:2000
• Immunogen: Recombinant Mouse LAIR1 protein
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with purified, recombinant Mouse LAIR1. Total IgG was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-LAIR1 antibody

Leukocyte-associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and can spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to "effector" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells.

Product Categories/Family for anti-LAIR1 antibody

ITIM/ITAM Immunoreceptors and Related Molecules

References

Meyaard L, et al. (1999) Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells. J Immunol. 162 (10): 5800-4.Meyaard L, et al. (2001) The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR). J Exp Med. 194 (1): 107-12.Xu M, et al. (2000) Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells. J Biol Chem. 275 (23): 17440-6.

NCBI and Uniprot Product Information

• NCBI GI #: 164698422
• NCBI GeneID: 52855
• NCBI Accession #: NP_001106945.1
• NCBI GenBank Nucleotide #: NM_001113474.1
• UniProt Accession #: Q8BG84; Q80UN5; Q8BHB6; Q8BRR6; Q8C6N8; Q8CEP5
• Molecular Weight: 25,128 Da
• NCBI Official Full Name: leukocyte-associated immunoglobulin-like receptor 1 isoform a
• NCBI Official Synonym Full Names: leukocyte-associated Ig-like receptor 1
• NCBI Official Symbol: Lair1
• NCBI Official Synonym Symbols: Lair-1; BB115266; D7Bwg0421e; 5133400O11Rik
• NCBI Protein Information: leukocyte-associated immunoglobulin-like receptor 1
• UniProt Protein Name: Leukocyte-associated immunoglobulin-like receptor 1
• Protein Family: Leukocyte-associated immunoglobulin-like receptor
• UniProt Gene Name: Lair1
• UniProt Synonym Gene Names: LAIR-1; mLAIR1

Uniprot Description

LAIR-1: an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region called the leukocyte receptor cluster, which contains at least 25 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 7 A1|7 2.31 cM

Cellular Component: plasma membrane