Rabbit anti-Mouse PIGR Monoclonal Antibody | anti-PIGR antibody

Recombinant Anti-PIGR Antibody, Rabbit Monoclonal

Cat. Num. AAA8111013

• Reactivity: Mouse
• Applications: ELISA, ELISA
• Purity: Protein A
• Synonyms: PIGR; Monoclonal Antibody; Recombinant Anti-PIGR Antibody; Rabbit Monoclonal; PIGR/Poly-Ig Receptor Antibody; Rabbit MAb; polymeric immunoglobulin receptor; Anti-Pigr Antibody; anti-PIGR antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Clone Number: 40
• Specificity: Mouse PIGR/Poly-Ig Receptor
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-PIGR antibody: ELISA (EIA), ELISA (EIA) (Cap)
• Application Notes: ELISA: 1:5000-1:10,000; ELISA (Cap): 1:250-1:2000; ELISA (Cap): This antibody will detect Mouse PIGR in ELISA pair set.; In a sandwich ELISA, it can be used as capture antibody.
• Antibody Type: Recombinant Antibody
• Immunogen: Recombinant Mouse PIGR protein
• Conjugation: Unconjugated
• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse PIGR extracellular domain (rM PIGR).
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-PIGR antibody

Polymeric immunoglobulin receptor, also known as PIGR, is a member of the immunoglobulin superfamily and a Fc receptor. The ectodomain of this receptor consists of five units with homology to the variable units of immunoglobulins and a transmembrane region, which also has some homology to certain immunoglobulin variable regions. PIGR is expressed on several glandular epithelia including those of liver and breast. The deduced amino-acid sequence has a length of 764 residues and shows an overall similarity of 56% and 64% with the rabbit and rat counterpart. PIGR mediates transcellular transport of polymeric immunoglobulin molecules, and thus facilitates the secretion of IgA and IgM. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment of PIGR.

References

Coyne, R. S. et al., 1995, J. Biol. Chem. 269 (50) :31620-31625. Kaetzel, C.S., 2001, Curr Biol. 11(1): R35-38.

NCBI and Uniprot Product Information

• NCBI GI #: 31981570
• NCBI GeneID: 18703
• NCBI Accession #: NP_035212.2
• NCBI GenBank Nucleotide #: NM_011082.3
• UniProt Accession #: O70570
• Molecular Weight: 84,999 Da
• NCBI Official Full Name: polymeric immunoglobulin receptor
• NCBI Official Synonym Full Names: polymeric immunoglobulin receptor
• NCBI Official Symbol: Pigr
• NCBI Protein Information: polymeric immunoglobulin receptor
• UniProt Protein Name: Polymeric immunoglobulin receptor
• Protein Family: Polymeric immunoglobulin receptor
• UniProt Gene Name: Pigr
• UniProt Synonym Gene Names: PIgR; Poly-Ig receptor

Uniprot Description

This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment ().