Western Blot (WB)
(Anti-TAX1BP3 rabbit polyclonal antibody at 1:500 dilution Lane A: A673 Whole Cell Lysate Lane B: HT-1080 Whole Cell Lysate Lane C: U-251 MG Whole Cell Lysate Lysates/proteins at 30 ug per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:14 kDa Observed band size:14 kDa)
Rabbit anti-Human TAX1BP3 Polyclonal Antibody | anti-TAX1BP3 antibody
Anti-TAX1BP3 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Western Blot
Purity
Protein A & Antigen Affinity
Synonyms
TAX1BP3; Polyclonal Antibody; Anti-TAX1BP3 Antibody; Rabbit Polyclonal; TAX1BP3 Antibody; Rabbit PAb; Antigen Affinity Purified; Tax1 (human T-cell leukemia virus type I) binding protein 3; Anti-TIP-1 Antibody; anti-TAX1BP3 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human TAX1BP3
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-TAX1BP3 antibody
Western Blot (WB)
Application Notes
WB: 1:500-1:2000
Immunogen
E Coli-derived Human TAX1BP3 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human TAX1BP3 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Western Blot (WB)
(Anti-TAX1BP3 rabbit polyclonal antibody at 1:500 dilution Lane A: A673 Whole Cell Lysate Lane B: HT-1080 Whole Cell Lysate Lane C: U-251 MG Whole Cell Lysate Lysates/proteins at 30 ug per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:14 kDa Observed band size:14 kDa)
Western Blot (WB)
(Anti-TAX1BP3 rabbit polyclonal antibody at 1:500 dilution Lane A: A673 Whole Cell Lysate Lane B: HT-1080 Whole Cell Lysate Lane C: U-251 MG Whole Cell Lysate Lysates/proteins at 30 ug per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:14 kDa Observed band size:14 kDa)
Related Product Information for anti-TAX1BP3 antibody
Tax interacting protein 1 (TIP-1, also known as Tax1BP3) is a molecular target that enables the selective binding of the HVGGSSV peptide within irradiated xenograft tumors. Genetic analysis revealed a homozygous missense mutation in TAX1BP3, which encodes a small PDZ domain-containing protein implicated in the regulation of the Wnt/beta-catenin signaling pathway, as the causative mutation. The mutation affects a conserved residue located at the core of the TAX1BP3 binding pocket and is predicted to impair the nature of a crucial hydrophobic patch, thereby interrupting the structure and stability of the protein, and its ability to interact with other proteins. TAX1BP3 is highly expressed in the heart and brain. Tax1bp3 inhibited the proliferation of colon cancer cells by antagonizing the transcriptional activity of beta-catenin.
References
Wang H, et al. (2010) Tip-1 translocation onto the cell plasma membrane is a molecular biomarker of tumor response to ionizing radiation. PLoS One 5 (8): e12051.Reinstein E, et al. (2015) Mutations in tax1bp3 cause dilated cardiomyopathy with septo-optic dysplasia. Hum Mutat 36 (4): 439-442.Han M, et al. (2012) The pdz protein tip-1 facilitates cell migration and pulmonary metastasis of human invasive breast cancer cells in athymic mice. Biochem Biophys Res Commun 422 (1): 139-145.
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Product Notes
The TAX1BP3 (Catalog #AAA8109600) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-TAX1BP3 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TAX1BP3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the TAX1BP3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TAX1BP3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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