Testing Data
(CCR2-transfected mouse L1.2 cells were stained with MBS631628, (filled histogram) or APC-conjugated isotype control (open histogram))
Rat anti-Mouse CCR2 Monoclonal Antibody | anti-CCR2 antibody
CCR2 (C-C Chemokine Receptor Type 2, C-C CKR-2, CC-CKR-2, CCR-2, CCR2, JE/FIC Receptor, MCP-1 Receptor, CD192, Cmkbr2) (APC)
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Dilution: Flow Cytometry: 10ul to label 1x10e6 cells.
Testing Data
(CCR2-transfected mouse L1.2 cells were stained with MBS631628, (filled histogram) or APC-conjugated isotype control (open histogram))
Testing Data
(CCR2-transfected mouse L1.2 cells were stained with MBS631628, (filled histogram) or APC-conjugated isotype control (open histogram))
Testing Data
(HEK293 cells transfected with rat CCR2 and eGP were stained with either (A) MBS631628 or (B) rat igG2b-APC isotype control.)
Testing Data
(HEK293 cells transfected with rat CCR2 and eGP were stained with either (A) MBS631628 or (B) rat igG2b-APC isotype control.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq]
Uniprot Description
CCR2: a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: cell soma; perinuclear region of cytoplasm; integral to plasma membrane; dendrite; cytoplasm; integral to membrane; plasma membrane; perikaryon; cytosol
Molecular Function: protein homodimerization activity; CCR2 chemokine receptor binding; C-C chemokine receptor activity; chemokine receptor activity
Biological Process: positive regulation of tumor necrosis factor biosynthetic process; viral reproduction; positive regulation of T-helper 1 type immune response; cytokine and chemokine mediated signaling pathway; negative regulation of adenylate cyclase activity; chemotaxis; JAK-STAT cascade; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; negative regulation of angiogenesis; positive regulation of interferon-gamma production; negative regulation of T-helper 2 type immune response; positive regulation of interleukin-2 production; response to wounding; dendritic cell chemotaxis; innate immune response; cellular defense response; immune response; positive regulation of alpha-beta T cell proliferation; blood vessel remodeling; negative regulation of eosinophil degranulation; cellular homeostasis; positive regulation of T cell activation; inflammatory response; positive regulation of inflammatory response
Research Articles on CCR2
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Product Notes
The CCR2 ccr2 (Catalog #AAA631628) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The CCR2 (C-C Chemokine Receptor Type 2, C-C CKR-2, CC-CKR-2, CCR-2, CCR2, JE/FIC Receptor, MCP-1 Receptor, CD192, Cmkbr2) (APC) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CCR2 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Suitable for use in Flow Cytometry. Dilution: Flow Cytometry: 10ul to label 1x10e6 cells. Researchers should empirically determine the suitability of the CCR2 ccr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CCR2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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