Immunohistochemistry (IHC)
(Immunochemical staining of human UROS in human stomach with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human UROS Polyclonal Antibody | anti-UROS antibody
Anti-UROS Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
UROS; Polyclonal Antibody; Anti-UROS Antibody; Rabbit Polyclonal; UROS Antibody; Rabbit PAb; Antigen Affinity Purified; uroporphyrinogen III synthase; Anti-UROIIIS Antibody; anti-UROS antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human UROS
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-UROS antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:50-1:200
Immunogen
E Coli-derived Human UROS fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human UROS fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human UROS in human stomach with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human UROS in human stomach with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-UROS antibody
UROS (uroporphyrinogen III synthase; EC 4.2.1.75) is the enzyme responsible for the formation of uroporphyrinogen III, the precursor of all cellular tetrapyrroles including haem, chlorophyll, and bilins. The UROS enzyme (also known as hydroxymethylbilane hydrolyase) is the fourth enzyme in the human heme biosynthetic pathway and catalyzes the cyclization of hydroxymethylbilane to uroporphyrinogen III during heme biosynthesis. A deficiency of this enzyme is associated with the very rare Gunther's disease or congenital erythropoietic porphyria, an autosomal recessive inborn error of metabolism. Congenital erythropoietic porphyria (CEP) is an inborn error of heme biosynthesis characterized by uroporphyrinogen III synthase (UROS) deficiency resulting in deleterious porphyrin accumulation in blood cells responsible for hemolytic anemia and cutaneous photosensitivity.
References
Tan FC, et al. (2008) Identification and characterization of the arabidopsis gene encoding the tetrapyrrole biosynthesis enzyme uroporphyrinogen iii synthase. Biochem J 410 (2): 291-299.Shaik AP, et al. (2012) Phylogenetic analysis of uroporphyrinogen iii synthase (uros) gene. Bioinformation 8 (25): 1265-1270.Blouin JM, et al. (2017) Missense uros mutations causing congenital erythropoietic porphyria reduce uros homeostasis that can be rescued by proteasome inhibition. Hum Mol Genet 26 (8): 1565-1576.Astrin KH, et al. (1991) Regional assignment of the human uroporphyrinogen iii synthase (uros) gene to chromosome 10q25.2----q26.3. Hum Genet 87 (1): 18-22.
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Product Notes
The UROS (Catalog #AAA8108149) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-UROS Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's UROS can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:50-1:200. Researchers should empirically determine the suitability of the UROS for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "UROS, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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