Immunohistochemistry (IHC)
(Immunochemical staining of human PNLIP in human pancreas with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections).)
Rabbit anti-Human PNLIP Monoclonal Antibody | anti-PNLIP antibody
Recombinant Anti-PNLIP Antibody, Rabbit Monoclonal
Gene Names
PNLIP; PL; PTL; PNLIPD
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A
Synonyms
PNLIP; Monoclonal Antibody; Recombinant Anti-PNLIP Antibody; Rabbit Monoclonal; PNLIP Antibody; Rabbit MAb; pancreatic lipase; Anti-PL Antibody; Anti-PNLIPD Antibody; Anti-PTL Antibody; anti-PNLIP antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone Number
120
Specificity
Human PNLIP
Purity/Purification
Protein A
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-PNLIP antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:1000-1:4000
Antibody Type
Recombinant Antibody
Immunogen
Recombinant Human PNLIP Protein
Conjugation
Unconjugated
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human PNLIP (rh PNLIP).
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human PNLIP in human pancreas with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections).)
Immunohistochemistry (IHC)
(Immunochemical staining of human PNLIP in human pancreas with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections).)
Related Product Information for anti-PNLIP antibody
PNLIP is an enzyme that belongs to the lipase family. Secreted from the pancreas, PNLIP is the primary lipase that hydrolyzes dietary fat molecules in the human digestive system, converting triglyceride substrates found in ingested oils to monoglycerides and free fatty acids. Bile salts secreted from the liver and stored in gallbladder are released into the duodenum where they coat and emulsify large fat droplets into smaller droplets, thus increasing the overall surface area of the fat, which allows the lipase to break apart the fat more effectively. The resulting monomers (2 free fatty acids and one 2-monoacylglycerol) are then moved by way of peristalsis along the small intestine to be absorbed into the lymphatic system by a specialized vessel called a lacteal.
References
Hegele RA, et al. (2001) Polymorphisms in PNLIP, encoding pancreatic lipase, and associations with metabolic traits. J Hum Genet. 46(6):320-4. Thomas A, et al. (2005) Role of the lid hydrophobicity pattern in pancreatic lipase activity. J Biol Chem. 280(48):40074-83. Colin DY, et al. (2008) Exploring the active site cavity of human pancreatic lipase. Biochem Biophys Res Commun. 370(3):394-8.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
51,157 Da
NCBI Official Full Name
pancreatic lipase
NCBI Official Synonym Full Names
pancreatic lipase
NCBI Official Symbol
PNLIP
NCBI Official Synonym Symbols
PL; PTL; PNLIPD
NCBI Protein Information
pancreatic triacylglycerol lipase; triacylglycerol acylhydrolase
UniProt Protein Name
Pancreatic triacylglycerol lipase
Protein Family
UniProt Gene Name
PNLIP
UniProt Synonym Gene Names
PL; PTL
UniProt Entry Name
LIPP_HUMAN
NCBI Description
This gene is a member of the lipase gene family. It encodes a carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides, and is essential for the efficient digestion of dietary fats. This gene is expressed specifically in the pancreas. [provided by RefSeq, Jul 2008]
Uniprot Description
PNLIP: a member of the lipase gene family. It encodes a carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides, and is essential for the efficient digestion of dietary fats. expressed specifically in the pancreas. [provided by RefSeq, Jul 2008]
Protein type: EC 3.1.1.3; Lipid Metabolism - glycerolipid; Secreted; Secreted, signal peptide; Hydrolase
Chromosomal Location of Human Ortholog: 10q26.1
Cellular Component: extracellular region
Molecular Function: triacylglycerol lipase activity; metal ion binding
Biological Process: phototransduction, visible light; cholesterol absorption; retinoid metabolic process; lipid catabolic process; lipid digestion
Disease: Pancreatic Lipase Deficiency
Research Articles on PNLIP
Similar Products
Product Notes
The PNLIP pnlip (Catalog #AAA8107011) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Anti-PNLIP Antibody, Rabbit Monoclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PNLIP can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:1000-1:4000. Researchers should empirically determine the suitability of the PNLIP pnlip for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PNLIP, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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