Rabbit VCAM-1 Polyclonal Antibody | anti-VCAM-1 antibody

VCAM-1 Rabbit Polyclonal

Cat. Num. AAA7605613

• Gene Names: Vcam1; VCAM1B
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: VCAM-1; Polyclonal Antibody; VCAM-1 Rabbit Polyclonal; anti-VCAM-1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 739

• Applicable Applications for anti-VCAM-1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Immunogen: Vascular cell adhesion molecule 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using MBS7605613 (VCAM-1 Antibody) at dilution of 1:200 . heat mediated antigen retrieved with Tris-EDTA buffer (pH9) .)

Western Blot (WB)

(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7605613 (VCAM-1 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 6981700
• NCBI GeneID: 25361
• NCBI Accession #: NP_037021.1
• NCBI GenBank Nucleotide #: NM_012889.1
• Molecular Weight: 81,246 Da
• NCBI Official Full Name: vascular cell adhesion protein 1
• NCBI Official Synonym Full Names: vascular cell adhesion molecule 1
• NCBI Official Symbol: Vcam1
• NCBI Official Synonym Symbols: VCAM1B
• NCBI Protein Information: vascular cell adhesion protein 1
• UniProt Protein Name: Vascular cell adhesion protein 1
• UniProt Gene Name: Vcam1
• UniProt Synonym Gene Names: Vcam-1; V-CAM 1; VCAM-1
• UniProt Entry Name: VCAM1_RAT

NCBI Description

binds integrin very late antigen (VLA4); plays a role in cell adhesion [RGD, Feb 2006]

Uniprot Description

VCAM1: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral

Cellular Component: apical part of cell; cell surface; early endosome; endoplasmic reticulum; external side of plasma membrane; extracellular space; filopodium; Golgi apparatus; integral to membrane; microvillus; podosome; sarcolemma

Molecular Function: amine oxidase activity; cell adhesion molecule binding; integrin binding

Biological Process: acute inflammatory response; aging; amine metabolic process; cell adhesion; cell-cell adhesion; cell-matrix adhesion; chronic inflammatory response; heart development; heterophilic cell adhesion; leukocyte adhesion; leukocyte tethering or rolling; membrane to membrane docking; positive regulation of T cell proliferation; response to ethanol; response to hypoxia; response to ionizing radiation; response to lipopolysaccharide; response to nicotine; response to nutrient; response to zinc ion; viral reproduction