Human Contactin associated protein like 2 (CNTNAP2) ELISA Kit | CNTNAP2 elisa kit

Human Contactin associated protein like 2 (CNTNAP2) ELISA Kit

Cat. Num. AAA7225107

• Gene Names: CNTNAP2; CDFE; NRXN4; AUTS15; CASPR2; PTHSL1
• Reactivity: Human
• Synonyms: Contactin associated protein like 2 (CNTNAP2); Human Contactin associated protein like 2 (CNTNAP2) ELISA Kit; CNTNAP2 elisa kit

• Reactivity: Human

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Assay Type: Competitive
• Detection Range: 0.5-10ng/mL
• Sensitivity: 0.1ng/mL
• Preparation and Storage: Store all reagents at 2-8 degree C.

Product Categories/Family for CNTNAP2 elisa kit

Neurobiology

NCBI and Uniprot Product Information

• NCBI GI #: 109731183
• NCBI GeneID: 26047
• Molecular Weight: 11,899 Da
• NCBI Official Full Name: Contactin associated protein-like 2
• NCBI Official Synonym Full Names: contactin associated protein-like 2
• NCBI Official Symbol: CNTNAP2
• NCBI Official Synonym Symbols: CDFE; NRXN4; AUTS15; CASPR2; PTHSL1
• NCBI Protein Information: contactin-associated protein-like 2; cell recognition molecule Caspr2; homolog of Drosophila neurexin IV
• UniProt Protein Name: Contactin-associated protein-like 2
• Protein Family: Contactin-associated protein
• UniProt Gene Name: CNTNAP2
• UniProt Synonym Gene Names: CASPR2; KIAA0868
• UniProt Entry Name: CNTP2_HUMAN

NCBI Description

This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.[provided by RefSeq, Mar 2010]

Uniprot Description

CNTNAP2: May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction. Associates with KCNA2. Predominantly expressed in nervous system. Belongs to the neurexin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q35

Cellular Component: Golgi apparatus; voltage-gated potassium channel complex; cell surface; cell soma; membrane; axon; early endosome; dendrite; integral to membrane; perikaryon; axolemma

Molecular Function: enzyme binding

Biological Process: striatum development; limbic system development; adult behavior; clustering of voltage-gated potassium channels; neuron recognition; transmission of nerve impulse; learning; brain development; social behavior; cerebral cortex development; thalamus development; cell adhesion; neurite development

Disease: Autism, Susceptibility To, 15; Cortical Dysplasia-focal Epilepsy Syndrome