Rabbit anti-Human CNTNAP2 Polyclonal Antibody | anti-CNTNAP2 antibody

CNTNAP2 (Contactin-associated Protein-like 2, Cell Recognition Molecule Caspr2, KIAA0868, CASPR2)

Cat. Num. AAA649761

• Gene Names: CNTNAP2; CDFE; NRXN4; AUTS15; CASPR2; PTHSL1
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: CNTNAP2; Polyclonal Antibody; CNTNAP2 (Contactin-associated Protein-like 2; Cell Recognition Molecule Caspr2; KIAA0868; CASPR2); Anti -CNTNAP2 (Contactin-associated Protein-like 2; anti-CNTNAP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CNTNAP2.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MQAAPRAGCGAALLLWIVSSCLCRAWTAPSTSQKCDEPLVSGLPHVAFSSSSSISGSYSPGYAKINKRGGAGGWSPSDSDHYQWLQVDFGNRKQISAIATQGRYSSSDWVTQYRMLYSDTGRNWKPYHQDGNIWAFPGNINSDGVVRHELQHPIIARYVRIVPLDWNGEGRIGLRIEVYGCSYWADVINFDGHVVLPYRFRNKKMKTLKDVIALNFKTSESEGVILHGEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVMTGSLLDDHHWHSVVIERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGIPFSGKPSSSSRKNFKGCMESINYNGVNITDLARRKKLEPSNVGNLSFSCVEPYTVPVFFNATSYLEVPGRLNQDLFSVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSQIDISSGSGLNDGQWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSFANVSIDMCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATCHNSIYEPSCEAYKHLGQTSNYYWIDPDGSGPLGPLKVYCNMTEDKVWTIVSHDLQMQTPVVGYNPEKYSVTQLVYSASMDQISAITDSAEYCEQYVSYFCKMSRLLNTPDGSPYTWWVGKANEKHYYWGGSGPGIQKCACGIERNCTDPKYYCNCDADYKQWRKDAGFLSYKDHLPVSQVVVGDTDRQGSEAKLSVGPLRCQGDRNYWNAASFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGKEDFIKLELKSATEVSFSFDVGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTRLELYSQLFVGGAGGQQGFLGCIRSLRMNGVTLDLEERAKVTSGFISGCSGHCTSYGTNCENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPATNARDSSSRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPCILLYISSFTTDFLAVLVKPTGSLQIRYNLGGTREPYNIDVDHRNMANGQPHSVNITRHEKTIFLKLDHYPSVSYHLPSSSDTLFNSPKSLFLGKVIETGKIDQEIHKYNTPGFTGCLSRVQFNQIAPLKAALRQTNASAHVHIQGELVESNCGASPLTLSPMSSATDPWHLDHLDSASADFPYNPGQGQAIRNGVNRNSAIIGGVIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGAESAESADAAIMNNDPNFTETIDESKKEWLI

• Applicable Applications for anti-CNTNAP2 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human CNTNAP2, aa1-1331 (NP_054860.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of CNTNAP2 expression in transfected 293T cell line by CNTNAP2 polyclonal antibody. Lane 1: CNTNAP2 transfected lysate (148.2kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-CNTNAP2 antibody

CNTNAP2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C omain,discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons.

Product Categories/Family for anti-CNTNAP2 antibody

Antibodies; Abs to Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 7662350
• NCBI GeneID: 26047
• NCBI Accession #: NP_054860.1
• NCBI GenBank Nucleotide #: NM_014141.5
• UniProt Accession #: Q9UHC6; Q14DG2; Q52LV1; Q5H9Q7; Q9UQ12; D3DWG2
• Molecular Weight: 148,167 Da
• NCBI Official Full Name: contactin-associated protein-like 2
• NCBI Official Synonym Full Names: contactin associated protein-like 2
• NCBI Official Symbol: CNTNAP2
• NCBI Official Synonym Symbols: CDFE; NRXN4; AUTS15; CASPR2; PTHSL1
• NCBI Protein Information: contactin-associated protein-like 2; cell recognition molecule Caspr2; homolog of Drosophila neurexin IV
• UniProt Protein Name: Contactin-associated protein-like 2
• Protein Family: Contactin-associated protein
• UniProt Gene Name: CNTNAP2
• UniProt Synonym Gene Names: CASPR2; KIAA0868
• UniProt Entry Name: CNTP2_HUMAN

NCBI Description

This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.[provided by RefSeq, Mar 2010]

Uniprot Description

Function: May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction.

Subunit structure: Associates with KCNA2

By similarity.

Subcellular location: Membrane; Single-pass type I membrane protein

Potential.

Tissue specificity: Predominantly expressed in nervous system.

Involvement in disease: Cortical dysplasia-focal epilepsy syndrome (CDFES) [MIM:610042]: A disease characterized by cortical dysplasia, focal epilepsy, relative macrocephaly, and diminished deep-tendon reflexes. Intractable focal seizures begin in early childhood, after which language regression, hyperactivity, impulsive and aggressive behavior, and mental retardation develop.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7Autism 15 (AUTS15) [MIM:612100]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.A chromosomal aberration involving CNTNAP2 is found in a patient with autism spectrum disorder. Paracentric inversion 46,XY,inv7(q11.22;q35). The inversion breakpoints disrupt the genes AUTS2 and CNTNAP2.

Sequence similarities: Belongs to the neurexin family.Contains 2 EGF-like domains.Contains 1 F5/8 type C domain.Contains 1 fibrinogen C-terminal domain.Contains 4 laminin G-like domains.

Sequence caution: The sequence BAA74891.1 differs from that shown. Reason: Erroneous initiation.