Rabbit FXYD domain containing ion transport regulator 2 Polyclonal Antibody | anti-FXYD2 antibody

Rabbit anti-human FXYD domain containing ion transport regulator 2 polyclonal Antibody

Cat. Num. AAA713759

• Gene Names: FXYD2; HOMG2; ATP1G1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: FXYD domain containing ion transport regulator 2; Polyclonal Antibody; Rabbit anti-human FXYD domain containing ion transport regulator 2 polyclonal Antibody; FXYD2; ATP1G1; HOMG2; MGC12372; anti-FXYD2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Form/Format: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3.
• Sequence Length: 66

• Applicable Applications for anti-FXYD2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Human FXYD2
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-26101
• Preparation and Storage: Upon receipt store at -20°C or -80°C. Avoid repeated freeze.

Related Product Information for anti-FXYD2 antibody

This gene encodes a member o f a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme s activity by inducing ion channel activity. Mutations in this gene have been associated with renal hypomagnesaemia. Alternatively spliced transcript variants encodingdifferent isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 15342034
• NCBI GeneID: 486
• NCBI Official Full Name: FXYD domain containing ion transport regulator 2
• NCBI Official Synonym Full Names: FXYD domain containing ion transport regulator 2
• NCBI Official Symbol: FXYD2
• NCBI Official Synonym Symbols: HOMG2; ATP1G1
• NCBI Protein Information: sodium/potassium-transporting ATPase subunit gamma; sodium pump gamma chain; Na(+)/K(+) ATPase subunit gamma; ATPase, Na+/K+ transporting, gamma 1 polypeptide
• UniProt Protein Name: Sodium/potassium-transporting ATPase subunit gamma
• Protein Family: Sodium/potassium-transporting ATPase
• UniProt Gene Name: FXYD2
• UniProt Synonym Gene Names: ATP1C; ATP1G1; Na(+)/K(+) ATPase subunit gamma
• UniProt Entry Name: ATNG_HUMAN

NCBI Description

This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.[provided by RefSeq, Feb 2011]

Uniprot Description

FXYD2: May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase. Defects in FXYD2 are the cause of hypomagnesemia type 2 (HOMG2); also known as dominant renal hypomagnesemia or hypomagnesemia with hypocalciuria. HOMG2 is a disorder due to primary renal wasting of magnesium. Plasma levels of other electrolytes are normal. The only abnormality found, in addition to low magnesium levels, is lowered renal excretion of calcium resulting in hypocalciuria. Belongs to the FXYD family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: intracellular membrane-bound organelle; basolateral plasma membrane; plasma membrane; sodium:potassium-exchanging ATPase complex

Molecular Function: transporter activity; sodium:potassium-exchanging ATPase activity; ion channel activity

Biological Process: transport; regulation of cell growth; transmembrane transport; potassium ion transport; regulation of cell proliferation

Disease: Hypomagnesemia 2, Renal