VCAM-1 active protein
Mouse VCAM-1
Gene Names
Vcam1; CD106; Vcam-1
Purity
>= 98% by SDS-PAGE gel and HPLC analyses.
Synonyms
VCAM-1; Mouse VCAM-1; Vascular Cell Adhesion Molecule 1; CD106; INCAM-100; MGC108734; MGC99561; VCAM; VCAM1; VCAM1B; VECAM1; VCAM-1 active protein
Host
CHO Cells
Purity/Purification
>= 98% by SDS-PAGE gel and HPLC analyses.
Form/Format
Lyophilized
Sequence
FKIEISPEYK TIAQIGDSMA LTCSTTGCES PLFSWRTQID SPLNAK VRTE GSKSVLTMEP VSFENEHSYL CTATCGSGKL ERSIHVDIYS F PKDPEIQFS GPLEVGKPVT VKCLAPDIYP VYRLEIDLFK GDQLMNR QEF SSEEMTKSLE TKSLEVTFTP VIEDIGKALV CRAKLHIDQI DS TLKERETV KELQVYISPR NTTISVHPST RLQEGGAVTM TCSSEGLP AP EIFWGRKLDN EVLQLLSGNA TLTLIAMRME DSGVYVCEGV NLI GRDKAEV ELVVQEKPFI VDISPGSQVA AQVGDSVVLT CAAIGCDSP S FSWRTQTDSP LNGVVRNEGA KSTLVLSSVG FEDEHSYLCA VTCL QRTLEK RTQVEVYSFP EDPVIKMSGP LVHGRPVTVN CTVPNVYPFD HLEIELLKGE TTLMKKYFLE EMGIKSLETK ILETTFIPTI EDTGK SLVCL ARLHSGEMES EPKQRQSVQP LYVNVAPKET TIWVSPSPIL EEGSPVNLTC SSDGIPAPKI LWSRQLNNGE LQPLSENTTL TFMSTK RDDS GIYVCEGINE AGISRKSVEL IIQVSPKDIQ LTVFPSKSVK E GDTVIISCT CGNVPETWII LKKKAKTGDM VLKSVDGSYT IRQAQLQ DAG IYECESKTEV GSQLRSLTLD VKGKEHNKNY FSPE
Sequence Length
739
Species
Mouse
Biological Activity
Determined by its ability to support the adhesion of human U937 cells.
Related Product Information for VCAM-1 active protein
VCAM is a 110 kDa, cell surface integral membrane glycoprotein that belongs to the Ig-related superfamily of adhesion molecules. The primary function of VCAM-1 is the mediation of leukocyte endothelial cell adhesion and signal transduction. VCAM-1 may play a vital role in the development of several diseases, including atherosclerosis and rheumatoid arthritis. The human VCAM-1 gene codes for a 715 amino acid transmembrane glycoprotein containing a 19 amino acid cytoplasmic domain, a 22 amino acid transmembrane domain, and a 674 amino acid extracellular domain. Recombinant Murine VCAM-1 is a 74.4 kDa glycoprotein comprising the extracellular domain (674 amino acid residues) of VCAM-1. Monomeric glycosylated VCAM-1 migrates at an apparent molecular weight of approximately 87-97 kDa by SDS-PAGE analysis under reducing conditions.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
38,372 Da
NCBI Official Full Name
Vascular cell adhesion protein 1
NCBI Official Synonym Full Names
vascular cell adhesion molecule 1
NCBI Official Symbol
Vcam1
NCBI Official Synonym Symbols
CD106; Vcam-1
NCBI Protein Information
vascular cell adhesion protein 1
UniProt Protein Name
Vascular cell adhesion protein 1
UniProt Gene Name
Vcam1
UniProt Synonym Gene Names
Vcam-1; V-CAM 1; VCAM-1
Uniprot Description
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Research Articles on VCAM-1
Similar Products
Product Notes
The VCAM-1 vcam1 (Catalog #AAA692527) is an Active Protein produced from CHO Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: FKIEISPEYK TIAQIGDSMA LTCSTTGCES PLFSWRTQID SPLNAK VRTE GSKSVLTMEP VSFENEHSYL CTATCGSGKL ERSIHVDIYS F PKDPEIQFS GPLEVGKPVT VKCLAPDIYP VYRLEIDLFK GDQLMNR QEF SSEEMTKSLE TKSLEVTFTP VIEDIGKALV CRAKLHIDQI DS TLKERETV KELQVYISPR NTTISVHPST RLQEGGAVTM TCSSEGLP AP EIFWGRKLDN EVLQLLSGNA TLTLIAMRME DSGVYVCEGV NLI GRDKAEV ELVVQEKPFI VDISPGSQVA AQVGDSVVLT CAAIGCDSP S FSWRTQTDSP LNGVVRNEGA KSTLVLSSVG FEDEHSYLCA VTCL QRTLEK RTQVEVYSFP EDPVIKMSGP LVHGRPVTVN CTVPNVYPFD HLEIELLKGE TTLMKKYFLE EMGIKSLETK ILETTFIPTI EDTGK SLVCL ARLHSGEMES EPKQRQSVQP LYVNVAPKET TIWVSPSPIL EEGSPVNLTC SSDGIPAPKI LWSRQLNNGE LQPLSENTTL TFMSTK RDDS GIYVCEGINE AGISRKSVEL IIQVSPKDIQ LTVFPSKSVK E GDTVIISCT CGNVPETWII LKKKAKTGDM VLKSVDGSYT IRQAQLQ DAG IYECESKTEV GSQLRSLTLD VKGKEHNKNY FSPE. It is sometimes possible for the material contained within the vial of "VCAM-1, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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