Wnt-7a active protein
Human Wnt-7a
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts
By similarity.
Subunit structure: Interacts with PORCN
By similarity.
Subcellular location: Secreted › extracellular space › extracellular matrix.
Tissue specificity: Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain.
Post-translational modification: Palmitoylation at Ser-206 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-73. Palmitoylation is necessary for proper trafficking to cell surface
By similarity.
Involvement in disease: Limb pelvis hypoplasia aplasia syndrome (LPHAS) [MIM:276820]: A syndrome of severe deficiency of the extremities due to hypo- or aplasia of one or more long bones of one or more limbs. Pelvic manifestations include hip dislocation, hypoplastic iliac bone and aplastic pubic bones. Thoracic deformity, unusual facies and genitourinary anomalies can be present.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6 Ref.7 Ref.8 Ref.9Fuhrmann syndrome (FUHRS) [MIM:228930]: Distinct limb-malformation disorder characterized also by various degrees of limb aplasia/hypoplasia and joint dysplasia.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6
Sequence similarities: Belongs to the Wnt family.
Research Articles on Wnt-7a
Similar Products
Product Notes
The Wnt-7a wnt7a (Catalog #AAA691883) is an Active Protein produced from HEK 293 Cells and is intended for research purposes only. The product is available for immediate purchase. The Human Wnt-7a reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: LGASIICNKI PGLAPRQRAI CQSRPDAIIV IGEGSQMGLD ECQFQF RNGR WNCSALGERT VFGKELKVGS REAAFTYAII AAGVAHAITA A CTQGNLSDC GCDKEKQGQY HRDEGWKWGG CSADIRYGIG FAKVFVD ARE IKQNARTLMN LHNNEAGRKI LEENMKLECK CHGVSGSCTT KT CWTTLPQF RELGYVLKDK YNEAVHVEPV RASRNKRPTF LKIKKPLS YR KPMDTDLVYI EKSPNYCEED PVTGSVGTQG RACNKTAPQA SGC DLMCCGR GYNTHQYARV WQCNCKFHWC CYVKCNTCSE RTEMYTCK. It is sometimes possible for the material contained within the vial of "Wnt-7a, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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