MCP4 Active Protein | Mcpt4 active protein
MCP4, Recombinant, Human (Macrophage/Monocyte Chemotactic Protein 4)
>98% by SDS-PAGE gel and HPLC
>98% by SDS-PAGE gel and HPLC
Stability: The lyophilized protein, though stable at room temperature, is best stored desiccated below 0 degree C. Reconstituted human MCP-4 should be stored in working aliquots at -20 degree C.
NCBI and Uniprot Product Information
Uniprot Description
Function: Has chymotrypsin-like activity. Hydrolyzes the amide bonds of synthetic substrates having Tyr and Phe residues at the P1 position. Preferentially hydrolyzes the 'Tyr-4-|-Ile-5' bond of angiotensin I and the 'Phe-20-|-Ala-21' bond of amyloid beta-protein, and is less active towards the 'Phe-8-|-His-9' bond of angiotensin I and the 'Phe-4-|-Ala-5' and 'Tyr-10-|-Glu-11' bonds of amyloid beta-protein. Involved in thrombin regulation and fibronectin processing. Ref.4 Ref.7
Enzyme regulation: Completely inhibited by serine protease inhibitors such as chymostatin, diisopropylfluorophosphate and phenylmethylsulfonyl fluoride, but not by p-tosyl-L-phenylalanine chloromethyl ketone, p-tosyl-L-lysine chloromethyl ketone, pepstatin, E-64, EDTA or o-phenanthroline. Also inhibited by lima bean trypsin inhibitor, soy bean trypsin inhibitor and human plasma alpha1-antichymotrysin.
Subunit structure: Monomer. Ref.4
Tissue specificity: Submucosal mast cells. In femoral muscle, detected in myocytes but not in mast cells. Ref.4
Disruption phenotype: Mice display an impaired ability to inactivate thrombin or degrade fibronectin in peritoneal cells. Ref.7
Sequence similarities: Belongs to the peptidase S1 family. Granzyme subfamily.Contains 1 peptidase S1 domain.
Biophysicochemical propertiespH dependence:Optimum pH is 9 at high salt concentrations.
Mass spectrometry: Molecular mass is 25187 Da from positions 21 - 246. Determined by MALDI. Ref.4
Sequence caution: The sequence BAB18732.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on Mcpt4
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Product Notes
The Mcpt4 mcpt4 (Catalog #AAA650692) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MCP4, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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