Mouse anti-Human NMRAL1 Polyclonal Antibody | anti-NMRAL1 antibody

NMRAL1 (NmrA-Like Family Domain-containing Protein 1, FLJ25918, HSCARG, SDR48A1)

Cat. Num. AAA642334

• Gene Names: NMRAL1; HSCARG; SDR48A1
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: NMRAL1; Polyclonal Antibody; NMRAL1 (NmrA-Like Family Domain-containing Protein 1; FLJ25918; HSCARG; SDR48A1); Anti -NMRAL1 (NmrA-Like Family Domain-containing Protein 1; anti-NMRAL1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human NMRAL1.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MVDKKLVVVFGGTGAQGGSVARTLLEDGTFKVRVVTRNPRKKAAKELRLQGAEVVQGDQDDQVIMELALNGAYATFIVTNYWESCSQEQEVKQGKLLADLARRLGLHYVVYSGLENIKKLTAGRLAAAHFDGKGEVEEYFRDIGVPMTSVRLPCYFENLLSHFLPQKAPDGKSYLLSLPTGDVPMDGMSVSDLGPVVLSLLKMPEKYVGQNIGLSTCRHTAEEYAALLTKHTRKVVHDAKMTPEDYEKLGFPGARDLANMFRFYALRPDRDIELTLRLNPKALTLDQWLEQHKGDFNLL

• Applicable Applications for anti-NMRAL1 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human NMRAL1, aa1-299 (NP_065728.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of NMRAL1 expression in transfected 293T cell line by NMRAL1 polyclonal antibody. Lane 1: HSCARG transfected lysate (32.89kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-NMRAL1 antibody

Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP+ levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP+. Binding to NADPH is necessary to form a stable dimer.

Product Categories/Family for anti-NMRAL1 antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 10190720
• NCBI GeneID: 57407
• NCBI Accession #: NP_065728.1
• NCBI GenBank Nucleotide #: NM_020677.3
• UniProt Accession #: Q9HBL8
• Molecular Weight: 33,344 Da
• NCBI Official Full Name: nmrA-like family domain-containing protein 1
• NCBI Official Synonym Full Names: NmrA-like family domain containing 1
• NCBI Official Symbol: NMRAL1
• NCBI Official Synonym Symbols: HSCARG; SDR48A1
• NCBI Protein Information: nmrA-like family domain-containing protein 1; short chain dehydrogenase/reductase family 48A, member 1
• UniProt Protein Name: NmrA-like family domain-containing protein 1
• Protein Family: NmrA-like family domain-containing protein
• UniProt Gene Name: NMRAL1
• UniProt Synonym Gene Names: HSCARG
• UniProt Entry Name: NMRL1_HUMAN

NCBI Description

This gene encodes an NADPH sensor protein that preferentially binds to NADPH. The encoded protein also negatively regulates the activity of NF-kappaB in a ubiquitylation-dependent manner. It plays a key role in cellular antiviral response by negatively regulating the interferon response factor 3-mediated expression of interferon beta. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Uniprot Description

NMRAL1: disulfide-linked (Probable). Belongs to the NmrA-type oxidoreductase family.

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: perinuclear region of cytoplasm; cytoplasm; nucleus