Western Blot (WB)
(Western Blot analysis of DUOXA1 expression in transfected 293T cell line by DUOXA1 polyclonal antibody. Lane 1: NIP transfected lysate (32.89kD). Lane 2: Non-transfected lysate.)
Mouse anti-Human DUOXA1 Polyclonal Antibody | anti-DUOXA1 antibody
DUOXA1 (Dual Oxidase Maturation Factor 1, Dual Oxidase Activator 1, Numb-interacting Protein, NIP, NUMBIP, FLJ32334)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot analysis of DUOXA1 expression in transfected 293T cell line by DUOXA1 polyclonal antibody. Lane 1: NIP transfected lysate (32.89kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of DUOXA1 expression in transfected 293T cell line by DUOXA1 polyclonal antibody. Lane 1: NIP transfected lysate (32.89kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Uniprot Description
DUOXA1: May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX1 (Probable). Belongs to the DUOXA family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q21.1
Cellular Component: endoplasmic reticulum membrane; integral to membrane; plasma membrane
Biological Process: protein transport; regulation of inflammatory response; hydrogen peroxide metabolic process; positive regulation of neuron differentiation
Research Articles on DUOXA1
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Product Notes
The DUOXA1 duoxa1 (Catalog #AAA6004574) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The DUOXA1 (Dual Oxidase Maturation Factor 1, Dual Oxidase Activator 1, Numb-interacting Protein, NIP, NUMBIP, FLJ32334) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DUOXA1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the DUOXA1 duoxa1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MATLGHTFPF YAGPKPTFPM DTTLASIIMI FLTALATFIV ILPGIRGKTR LFWLLRVVTS LFIGAAILGT PVQQLNETIN YNEEFTWRLG ENYAEEYAKA LEKGLPDPVL YLAEKFTPRS PCGLYRQYRL AGHYTSAMLW VAFLCWLLAN VMLSMPVLVY GGYMLLATGI FQLLALLFFS MATSLTSPCP LHLGASVLHT HHGPAFWITL TTGLLCVLLG LAMAVAHRMQ PHRLKAFFNQ SVDEDPMLEW SPEEGGLLSP RYRSMADSPK SQDIPLSEAS STKAYCKEAH PKDPDCAL. It is sometimes possible for the material contained within the vial of "DUOXA1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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